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Browsing by Author "Waghela, Bhargav N"

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AGE‑RAGE synergy influences programmed cell death signaling to promote cancer

Waghela, Bhargav N; Vaidya, Foram U; Kishu Ranjan, Tiwari; Abu Sufiyan Chhipa, Budhi Sagar (2020)

Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are predominantly synthesized during chronic hyperglycemic ...
Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes

Lunagariya, Miral V; Thakor, Khyati P; Waghela, Bhargav N; Vaidya, Foram U; Patel, Chadramani Pathak & Mohan N (2016-12-07)

The square planar Pt(II) complexes of the type [Pt(Ln)(Cl2)] (where Ln = L1-3 = thiophene-2- carboxamide derivatives and L4-6 = thiophene-2-carbothioamide derivatives) have been synthesized and characterized by physicochemical ...
Design, synthesis, pharmacological evaluation and DNA interaction studies of binuclear Pt(II) complexes with pyrazolo[1,5‐a]pyrimidine scaffold

Lunagariya, Miral V; Thakor, Khyati P; Waghela, Bhargav N; Pathak, Chadramani (2017-11-09)

Substituted pyrazolo[1,5‐a]pyrimidine ligands were synthesized by cyclization, using 3‐(thiophen‐2‐yl)‐1H‐pyrazol‐5‐amine with substituted enones (3‐phenyl‐ 1‐(pyridin‐2‐yl)prop‐2‐en‐1‐one) in presence ofKOHandDMFas solvent ...
Evaluation of antimitotic activity of herbal extracts using plant‑based model systems and their cytotoxic potential against human colon carcinoma cells

Parmar, Mayur P; Waghela, Bhargav N; Vaidya, Foram U; Pathak, Chandramani; Parmar, Dipak V (2022-01-18)

Objective: The aim of this study was to screen plant extracts for antimitotic activity using Vigna radiata germination inhibition assay, followed by Allium cepa root tip assay and evaluation of their cytotoxic potential ...
Molecular insights of NADPH oxidases and its pathological consequences

Waghela, Bhargav N; Vaidya, Foram U; Agrawal, Yashika; Santra, Manas Kumar; Mishra, Vinita (2020-09-01)

Reactive oxygen species (ROS), formed by the partial reduction of oxygen, were for aong time considered to be a byproduct of cellular metabolism. Since, increase in cellular levels of ROS results in oxidative stress leading ...
Upregulation of NOX 2 and Nrf 2 Promotes 5 Fluorouracil Resistance of Human Colon Carcinoma (HCT 116) Cells

Waghela, Bhargav N; Vaidya, Foram U; Pathak, Chandramani (2020-09-21)

Altered expression of cellular redox genes and proteins contributes to invasion, metastasis, and drug resistance in cancer. NADPH oxidase (NOX) isoforms are the pro_oxidant enzymes that generate ROS as a primary product. ...

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