Abstract:
Hydroalcoholic extract of fruits of Vernonia anthelmintica Willd. (Family: Asteraceae) (HAEVA) was assessed for its
anti-inflammatory activity and anti-arthritic activity by in vitro methods. In vitro anti-inflammatory activity and anti arthritic activity were evaluated using HRBC (Human Red Blood Cell) membrane stabilization method and inhibition
of protein denaturation method respectively. The present finding exhibited concentration dependent HRBC membrane
stabilization and inhibition of protein denaturation activity of HAEVA. The maximum membrane stabilization was
found to be 89.92% and maximum inhibition of protein denaturation was found to be 98.57% at 1000μg/ml dose. The
extract showed HRBC membrane stabilization at a concentration range of 100-1000μg/ml significantly (p<0.01) while
inhibition of protein denaturation activity at a concentration range of 250-1000 μg/ml significantly (p<0.01). The
results obtained in the present study indicate that HAEVA can be a potential source of anti-inflammatory agents.
