Abstract:
Inflammatory diseases are still one of the most important heath-problems in the world. Most of anti inflammatory drugs such as non–steroidal anti-inflammatory drugs (NSAIDS) have number of adverse effects
hence there are a need to develop safe and new anti-inflammatory formulation with minimum side effects.
Present study focused on investigating and comparing anti-inflammatory potential of hydroalcoholic extracts of
Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris and their combinations. Inhibition of heat induced
HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The combination ratio of
hydroalcoholic extracts of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris (2:5:3) showed the most
significant membrane stabilizing action on HRBC membrane as compare tohydroalcoholic extracts of individual
drugs and theirother combinations. The present study revealed that the proper combination of Tinospora
cordifolia, Boerhavia diffusa, Tribulus terrestris gives more effective anti-inflammatory activity than any of the
individual drug.
