Abstract:
The present work was designed to develop suitable transdermal matrix patches using the polymer blends of hydroxy propyl methyl
cellulose (HPMC) and Eudragit RL100 (ERL) with triethyl citrate as a plasticizer in group A and in group B, other than HPMC
and ERL, crosslinking agent, succinic acid was added. A 32 full factorial design was employed for both groups. The concentration
of HPMC and ERL were used as independent variables, while percentage drug release was selected as dependent variable. Physical
evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion
studies were performed using cellulose acetate membrane (pore size 0.45 µ) in a Franz’s diffusion cell. The concentration of diffused
drug was measured using UV-visible spectrophotometer (V-530, Jasco) at λmax 272 nm. The experimental results shows that the
transdermal drug delivery system (TDDS) containing ERL in higher proportion gives sustained the release of drug and patches
containing crosslinking agent shows more release than those do not contains succinic acid.
