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Influence of Crosslinking Agent on the Release of Drug from the Matrix Transdermal Patches of HPMC/Eudragit RL 100 Polymer Blends

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dc.contributor.author Garala, Kevin
dc.contributor.author Shah, Pratik
dc.date.accessioned 2023-05-26T04:40:02Z
dc.date.available 2023-05-26T04:40:02Z
dc.date.issued 2010-01
dc.identifier.citation Garala, Kevin C. and Shah, Pratik H.(2010) 'Influence of Crosslinking Agent on the Release of Drug from the Matrix Transdermal Patches of HPMC/Eudragit RL 100 Polymer Blends', Journal of Macromolecular Science, Part A, 47: 3, 273 — 281, ISSN: 1060-1325 print / 1520-5738 online en_US
dc.identifier.issn 1520-5738
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1115
dc.description.abstract The present work was designed to develop suitable transdermal matrix patches using the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit RL100 (ERL) with triethyl citrate as a plasticizer in group A and in group B, other than HPMC and ERL, crosslinking agent, succinic acid was added. A 32 full factorial design was employed for both groups. The concentration of HPMC and ERL were used as independent variables, while percentage drug release was selected as dependent variable. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 µ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (V-530, Jasco) at λmax 272 nm. The experimental results shows that the transdermal drug delivery system (TDDS) containing ERL in higher proportion gives sustained the release of drug and patches containing crosslinking agent shows more release than those do not contains succinic acid. en_US
dc.language.iso en en_US
dc.publisher Journal of Macromolecular Science, Part A en_US
dc.subject HPMC en_US
dc.subject Eudragit RL 100 en_US
dc.subject crosslinking agent en_US
dc.subject tramadol HCl en_US
dc.subject transdermal delivery en_US
dc.title Influence of Crosslinking Agent on the Release of Drug from the Matrix Transdermal Patches of HPMC/Eudragit RL 100 Polymer Blends en_US
dc.type Article en_US


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