DSpace Repository

Design and development of solid nanoparticulate dosage forms of telmisartan for bioavailability enhancement by integration of experimental design and principal component analysis

Show simple item record

dc.contributor.author Patel, Jaydeep
dc.contributor.author Dhingani, Anjali
dc.contributor.author Garala, Kevin
dc.contributor.author Raval, Mihir
dc.contributor.author Sheth, Navin
dc.date.accessioned 2023-05-26T05:42:04Z
dc.date.available 2023-05-26T05:42:04Z
dc.date.issued 2014-03
dc.identifier.citation Patel, J. ,Dhingani, A. ,Garala, K. ,Raval, M. ,Sheth, N. (2014). Design and development of solid nanoparticulate dosage forms of telmisartan for bioavailability enhancement by integration of experimental design and principal component analysis. Powder Technology, Elsevier. 258 (2014) 331–34, ISSN : 0032-5910. http://dx.doi.org/10.1016/j.powtec.2014.03.001 en_US
dc.identifier.issn 0032-5910
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1117
dc.description.abstract Aim of the present investigation was to develop nanoparticulate solid oral dosage forms of a poorly water soluble antihypertensive agent, telmisartan (TLM) by converting the optimized batch of drug loaded nanosuspensions into a tablet dosage form using lyophilization technique. The TLM loaded nanosuspensions were optimized by implementation of 32 full factorial design along with principal component analysis (PCA) with concentration of stabilizer and amount of milling agents as factors. The optimized batch of TLM loaded nanosuspension exhibited a mean particle size of 334.67 ± 10.43 nm. The results of various instrumental techniques illustrated retention of drug crystallinity after milling and lyophilization. The results of in vitro drug release study of tablets containing drug nanocrystals revealed remarkable improvement in the dissolution rate as compared to the marketed tablet (Sartel® 20). The results of in vivo pharmacokinetic study on Wister rats revealed 1.5-fold enhancement in oral bioavailability for tablets containing TLM nanocrystals against the marketed tablets. The present study proposed nanosuspension as a suitable approach for developing nanosized solid oral dosage forms of poorly water soluble drugs like telmisartan using design of experiment and principal component analysis as two important paradigms of quality by design technique. en_US
dc.language.iso en en_US
dc.publisher Powder Technology, Elsevier en_US
dc.subject Bioavailability en_US
dc.subject Nanosuspension en_US
dc.subject Nanocrystals en_US
dc.subject Principal component analysis en_US
dc.subject Quality by design en_US
dc.subject Telmisartan en_US
dc.title Design and development of solid nanoparticulate dosage forms of telmisartan for bioavailability enhancement by integration of experimental design and principal component analysis en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account