Abstract:
The objective of the present investigation was to develop microemulsion (ME) based
transdermal systems of highly water soluble drug, Atenolol by quality by design
technique. Atenolol loaded W/O MEs were optimized using D-optimal design with
concentrations of oil, surfactants mixture and water as independent variables which was
converted into microemulsion based gel (MBG). The results of in vitro permeation of the
optimized batch of Atenolol loaded MBG revealed significant increase in permeability
parameters as compared to its convention gel. All these results suggested suitability of
W/O type MEs as carriers for transdermal delivery of highly water soluble drug,
Atenolol.
