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Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis

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dc.contributor.author Dhingani, Anjali
dc.contributor.author Patel, Jaydeep
dc.contributor.author Garala, Kevin
dc.contributor.author Dharamsi, Abhay
dc.date.accessioned 2023-05-27T02:01:08Z
dc.date.available 2023-05-27T02:01:08Z
dc.date.issued 2013
dc.identifier.citation Dhingani Anjali, Patel Jaydeep, Garala Kevin and Dharamsi Abhay, Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis, Pharmaceutical Nanotechnology 2013; 1(4) . https://dx.doi.org/10.2174/22117385113016660009 en_US
dc.identifier.issn 2211-7393
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1120
dc.description We would like to thank Torrent Research Center for providing gift sample of Lercanidipine HCl. en_US
dc.description.abstract The objective of the present research was to design and develop microemulsion (ME) based transdermal systems of poorly water soluble drug, Lercanidipine hydrochloride (LDPH) by assimilation of central composite design and principal component analysis (PCA) as two important paradigms of quality by design. LDPH loaded O/W MEs were optimized with amounts of oil (Capryol 90), surfactants mixture (Cremophor EL and Ethanol) and water as independent variables along with cumulative amount of drug permeated in 24 h (Q24), flux (Jss) and lag time (tL) as dependent variables. The optimized batch of LDPH loaded ME was successfully converted into microemulsion based gel (MBG) for increased patient compliance. The results of in vitro skin permeation of the optimized batch of LDPH loaded MBG revealed significant increase in permeability parameters as compared to its convention formulation. The values of Jss for optimized batch of LDPH loaded MBGs (196.47 g/cm2 h) revealed 7.95 cm2 area requirement to obtain the desired input rate of LDPH within 24 h application. All these concluded suitability of experimental design and PCA for design and development of O/W type MEs as carriers for transdermal delivery of poorly water soluble drug, LDPH. en_US
dc.language.iso en en_US
dc.publisher Pharmaceutical Nanotechnology, Bentham Science Publishers en_US
dc.subject Central composite design en_US
dc.subject lercanidipine hydrochloride en_US
dc.subject microemulsion en_US
dc.subject principal component analysis en_US
dc.subject quality by design en_US
dc.subject transdermal drug delivery en_US
dc.title Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis en_US
dc.type Article en_US


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