dc.contributor.author |
Dhingani, Anjali |
|
dc.contributor.author |
Patel, Jaydeep |
|
dc.contributor.author |
Garala, Kevin |
|
dc.contributor.author |
Dharamsi, Abhay |
|
dc.date.accessioned |
2023-05-27T02:01:08Z |
|
dc.date.available |
2023-05-27T02:01:08Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
Dhingani Anjali, Patel Jaydeep, Garala Kevin and Dharamsi Abhay, Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis, Pharmaceutical Nanotechnology 2013; 1(4) . https://dx.doi.org/10.2174/22117385113016660009 |
en_US |
dc.identifier.issn |
2211-7393 |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1120 |
|
dc.description |
We would like to thank Torrent Research Center for providing gift sample of Lercanidipine HCl. |
en_US |
dc.description.abstract |
The objective of the present research was to design and develop microemulsion (ME) based transdermal systems of poorly water soluble drug, Lercanidipine hydrochloride (LDPH) by assimilation of central composite design and
principal component analysis (PCA) as two important paradigms of quality by design. LDPH loaded O/W MEs were optimized with amounts of oil (Capryol 90), surfactants mixture (Cremophor EL and Ethanol) and water as independent
variables along with cumulative amount of drug permeated in 24 h (Q24), flux (Jss) and lag time (tL) as dependent variables. The optimized batch of LDPH loaded ME was successfully converted into microemulsion based gel (MBG) for increased patient compliance. The results of in vitro skin permeation of the optimized batch of LDPH loaded MBG revealed
significant increase in permeability parameters as compared to its convention formulation. The values of Jss for optimized
batch of LDPH loaded MBGs (196.47 g/cm2
h) revealed 7.95 cm2
area requirement to obtain the desired input rate of
LDPH within 24 h application. All these concluded suitability of experimental design and PCA for design and development of O/W type MEs as carriers for transdermal delivery of poorly water soluble drug, LDPH. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Pharmaceutical Nanotechnology, Bentham Science Publishers |
en_US |
dc.subject |
Central composite design |
en_US |
dc.subject |
lercanidipine hydrochloride |
en_US |
dc.subject |
microemulsion |
en_US |
dc.subject |
principal component analysis |
en_US |
dc.subject |
quality by design |
en_US |
dc.subject |
transdermal drug delivery |
en_US |
dc.title |
Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis |
en_US |
dc.type |
Article |
en_US |