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Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery

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dc.contributor.author Patel, Jaydeep
dc.contributor.author Garala, Kevin
dc.contributor.author Patel, Anjali
dc.contributor.author Raval, Mihir
dc.contributor.author Sheth, Navin
dc.date.accessioned 2023-05-27T03:30:45Z
dc.date.available 2023-05-27T03:30:45Z
dc.date.issued 2011-04
dc.identifier.citation Patel, J. ,Patel, A. ,Garala, K. ,Raval, M. ,Sheth, N. (2011). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation (Medknow Publications), Volume 1 Issue 2, ISSN : 2230-973X, DOI: 10.4103/2230-973X.82431 en_US
dc.identifier.issn 2230-973X
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1123
dc.description The authors are very thankful to Abitec Corp. (USA), Gettefosse (India), BASF (India), Sasol (Germany), Nikko Chemicals (Japan), and Corel Pharma (India) for providing gift samples. en_US
dc.description.abstract Background and Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water soluble TEL. Materials and Methods: The solubility of TEL in various oils was determined to identify the oil phase of a SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. A SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation, dilution, droplet size, zeta potential, pH, refractive index, and viscosity. Results: The developed SNEDDS formulation contained TEL (20mg), Tween® 20 (43.33%w/w), Carbitol® (21.67%w/w), and Acrysol® EL 135 (32%w/w). The optimized formulation of the TEL-loaded SNEDDS exhibited a complete in vitro drug release in 15min as compared with the plain drug, which had a limited dissolution rate. It was also compared with the pure drug suspension by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of TEL from the SNEDDS compared with the pure drug suspension. Conclusions: These results suggest the potential use of the SNEDDS to improve the dissolution and oral bioavailability of poorly water soluble TEL. en_US
dc.language.iso en en_US
dc.publisher International Journal of Pharmaceutical Investigation (Medknow Publications) en_US
dc.subject Bioavailability en_US
dc.subject poor water solubility en_US
dc.subject self-nanoemulsifying drug delivery system en_US
dc.subject telmisartan en_US
dc.title Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery en_US
dc.type Article en_US


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