dc.contributor.author |
Patel, Jaydeep |
|
dc.contributor.author |
Garala, Kevin |
|
dc.contributor.author |
Patel, Anjali |
|
dc.contributor.author |
Raval, Mihir |
|
dc.contributor.author |
Sheth, Navin |
|
dc.date.accessioned |
2023-05-27T03:30:45Z |
|
dc.date.available |
2023-05-27T03:30:45Z |
|
dc.date.issued |
2011-04 |
|
dc.identifier.citation |
Patel, J. ,Patel, A. ,Garala, K. ,Raval, M. ,Sheth, N. (2011). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. International Journal of Pharmaceutical Investigation (Medknow Publications), Volume 1 Issue 2, ISSN : 2230-973X, DOI: 10.4103/2230-973X.82431 |
en_US |
dc.identifier.issn |
2230-973X |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1123 |
|
dc.description |
The authors are very thankful to Abitec Corp. (USA), Gettefosse (India),
BASF (India), Sasol (Germany), Nikko Chemicals (Japan), and Corel
Pharma (India) for providing gift samples. |
en_US |
dc.description.abstract |
Background and Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of
the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral
bioavailability of poorly water soluble TEL. Materials and Methods: The solubility of TEL in various oils was determined
to identify the oil phase of a SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify
the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. A
SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation,
dilution, droplet size, zeta potential, pH, refractive index, and viscosity. Results: The developed SNEDDS formulation
contained TEL (20mg), Tween®
20 (43.33%w/w), Carbitol®
(21.67%w/w), and Acrysol®
EL 135 (32%w/w). The optimized
formulation of the TEL-loaded SNEDDS exhibited a complete in vitro drug release in 15min as compared with the plain
drug, which had a limited dissolution rate. It was also compared with the pure drug suspension by oral administration
in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of TEL from the SNEDDS
compared with the pure drug suspension. Conclusions: These results suggest the potential use of the SNEDDS to improve
the dissolution and oral bioavailability of poorly water soluble TEL. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
International Journal of Pharmaceutical Investigation (Medknow Publications) |
en_US |
dc.subject |
Bioavailability |
en_US |
dc.subject |
poor water solubility |
en_US |
dc.subject |
self-nanoemulsifying drug delivery system |
en_US |
dc.subject |
telmisartan |
en_US |
dc.title |
Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery |
en_US |
dc.type |
Article |
en_US |