Abstract:
In the present study we investigated the effect of polyamidoamine (PAMAM) dendrimers on the aqueous solubility
of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimers in distilled water.
The effect of variables, such as pH condition, concentration, temperature and generation (molecule size) of dendrimer,
has been investigated. Results showed that the solubility of aceclofenac in the dendrimer solutions was proportional
to dendrimer concentration. The order in which the dendrimers increased the solubility at a constant pH condition
was G3 > G0. The influence of dendrimer solution pH on the solubility enhancement of aceclofenac suggests that it
involves an electrostatic interaction between the carboxyl group of the aceclofenac molecule and the amine groups
of the dendrimer molecule. The solubility of aceclofenac was inversely proportional to the temperature of dendrimer
solution.Different generation (G0 and G3) PAMAM dendrimers have the potential to significantly enhance the solubility
of poor water-soluble drugs.
