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Solubility of aceclofenac in polyamidoamine dendrimer solutions

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dc.contributor.author Patel, Jaydeep
dc.contributor.author Garala, Kevin
dc.contributor.author Basu, Biswajit
dc.contributor.author Raval, Mihir
dc.contributor.author Dharamsi, Abhay
dc.date.accessioned 2023-05-27T03:52:15Z
dc.date.available 2023-05-27T03:52:15Z
dc.date.issued 2011-07
dc.identifier.citation Patel J, Garala K, Basu B, Raval M, Dharamsi A. Solubility of aceclofenac in polyamidoamine dendrimer solutions. Int J Pharma Investig 2011;1:135-8. en_US
dc.identifier.issn 2230-9713
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1125
dc.description We are grateful to Dendritech Inc. (USA) for the gift sample of dendrimer. We are thankful to Rantus Pharma Pvt. Ltd. (Hyderabad, India) for providing gift sample of aceclofenac. en_US
dc.description.abstract In the present study we investigated the effect of polyamidoamine (PAMAM) dendrimers on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimers in distilled water. The effect of variables, such as pH condition, concentration, temperature and generation (molecule size) of dendrimer, has been investigated. Results showed that the solubility of aceclofenac in the dendrimer solutions was proportional to dendrimer concentration. The order in which the dendrimers increased the solubility at a constant pH condition was G3 > G0. The influence of dendrimer solution pH on the solubility enhancement of aceclofenac suggests that it involves an electrostatic interaction between the carboxyl group of the aceclofenac molecule and the amine groups of the dendrimer molecule. The solubility of aceclofenac was inversely proportional to the temperature of dendrimer solution.Different generation (G0 and G3) PAMAM dendrimers have the potential to significantly enhance the solubility of poor water-soluble drugs. en_US
dc.language.iso en en_US
dc.publisher International Journal of Pharmaceutical Investigation en_US
dc.subject Aceclofenac en_US
dc.subject dendrimer en_US
dc.subject polyamidoamine dendrimers en_US
dc.subject solubility enhancement en_US
dc.title Solubility of aceclofenac in polyamidoamine dendrimer solutions en_US
dc.type Article en_US


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