Abstract:
In the present work, monolithic matrix transdermal systems containing tramadol HCl were prepared using various
ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl
citrate as a plasticizer. A 32
full factorial design was employed. The concentration of HPMC and ES were used as
independent variables, while percentage drug release was selected as dependent variable. Physical evaluation was
performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro
diffusion studies were performed using cellulose acetate membrane (pore size 0.45 μ) in a Franz’s diffusion cell.
The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at λ max 272
nm. The experimental results shows that the transdermal drug delivery system (TDDS) containing ES in higher
proportion gives sustained the release of drug.
