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Formulation and in-vitro characterization of monolithic matrix Transdermal systems using hpmc/eudragit s 100 polymer blends

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dc.contributor.author Garala, Kevin
dc.contributor.author Shinde, Anil
dc.contributor.author Shah, Pratik
dc.date.accessioned 2023-05-27T04:03:52Z
dc.date.available 2023-05-27T04:03:52Z
dc.date.issued 2009-12
dc.identifier.citation Garala, Kevin & Shinde, Anilkumar & Shah, Pratik. (2009). Formulation and in-vitro characterization of monolithic matrix transdermal systems using HPMC/Eudragit S 100 polymer blends. International Journal of Pharmacy and Pharmaceutical Sciences. 1. en_US
dc.identifier.issn 0975-1491
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1126
dc.description.abstract In the present work, monolithic matrix transdermal systems containing tramadol HCl were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as dependent variable. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 μ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at λ max 272 nm. The experimental results shows that the transdermal drug delivery system (TDDS) containing ES in higher proportion gives sustained the release of drug. en_US
dc.language.iso en en_US
dc.publisher International Journal of Pharmacy and Pharmaceutical Sciences en_US
dc.subject HPMC en_US
dc.subject Eudragit S 100 en_US
dc.subject Tramadol HCl en_US
dc.subject Transdermal Delivery en_US
dc.title Formulation and in-vitro characterization of monolithic matrix Transdermal systems using hpmc/eudragit s 100 polymer blends en_US
dc.type Article en_US


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