Abstract:
A simple, sensitive, specific, spectrophotometric method was developed for the detection
of Olmesartan medoxomil (OLM) in bulk and pharmaceutical formulations. The optimum
conditions for the analysis of the drug were established. OLM was subjected to stress
degradation under different conditions recommended by the International Conference
on Harmonization (ICH). The samples so generated were used for degradation studies
using the developed method. The λmax of the OLM was found to be 257 nm. The method
exhibited high sensitivity, with linearity, in the 2 to 20 μg/ml range. The lower limit of
detection and the limit of quantify cation were found to be 1.012 μg/ml and 3.036 μg/
ml, respectively. All the calibration curves demonstrated a linear relationship between
the absorbance and concentration, with the correlation coefficient higher than 0.99. The
regression equation of the curve was Y = 0.0579x + 0.0006. The precision of the method
was found to be 40.043 ± 0.067 against the label claim of 40 mg. The percentage recovery
was found to be 101.32 ± 0.452. The sample solution was stable for up to two hours. Hence,
it could be concluded that the proposed method would be suitable for the analysis of
OLM in bulk and pharmaceutical formulations
