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Development of the UV spectrophotometric method of Olmesartan medoxomil in bulk drug and pharmaceutical formulation and stress degradation studies

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dc.contributor.author Patel, Jaydeep
dc.contributor.author Garala, Kevin
dc.contributor.author Patel, Anjali
dc.contributor.author Raval, Mihir
dc.contributor.author Sheth, Navin
dc.date.accessioned 2023-05-27T04:16:51Z
dc.date.available 2023-05-27T04:16:51Z
dc.date.issued 2011-03
dc.identifier.citation Jaydeep Patel, Garala Kevin, Anjali Patel, Mihir Raval, Navin Sheth, Development of the UV spectrophotometric method of Olmesartan medoxomil in bulk drug and pharmaceutical formulation and stress degradation studies, Pharmaceutical Methods, Volume 2, Issue 1, 2011, Pages 36-41, ISSN 2229-4708, https://doi.org/10.4103/2229-4708.81092. en_US
dc.identifier.issn 2229-4708
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1127
dc.description We would like to thank Torrent Research Center for providing the gift sample of Olmesartan medoxomil. en_US
dc.description.abstract A simple, sensitive, specific, spectrophotometric method was developed for the detection of Olmesartan medoxomil (OLM) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of the drug were established. OLM was subjected to stress degradation under different conditions recommended by the International Conference on Harmonization (ICH). The samples so generated were used for degradation studies using the developed method. The λmax of the OLM was found to be 257 nm. The method exhibited high sensitivity, with linearity, in the 2 to 20 μg/ml range. The lower limit of detection and the limit of quantify cation were found to be 1.012 μg/ml and 3.036 μg/ ml, respectively. All the calibration curves demonstrated a linear relationship between the absorbance and concentration, with the correlation coefficient higher than 0.99. The regression equation of the curve was Y = 0.0579x + 0.0006. The precision of the method was found to be 40.043 ± 0.067 against the label claim of 40 mg. The percentage recovery was found to be 101.32 ± 0.452. The sample solution was stable for up to two hours. Hence, it could be concluded that the proposed method would be suitable for the analysis of OLM in bulk and pharmaceutical formulations en_US
dc.language.iso en en_US
dc.publisher Medknow Publications en_US
dc.subject Estimation en_US
dc.subject Olmesartan medoxomil en_US
dc.subject spectroscopy en_US
dc.subject stress degradation study en_US
dc.title Development of the UV spectrophotometric method of Olmesartan medoxomil in bulk drug and pharmaceutical formulation and stress degradation studies en_US
dc.type Article en_US


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