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Formulation and In Vitro Evaluation of Periodontal Films Containing Metronidazole

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dc.contributor.author Basu, Biswajit
dc.contributor.author Garala, Kevin
dc.contributor.author Tyagi, Manojkumar
dc.contributor.author Prabhushankar, G.
dc.contributor.author Sathesh Babu, P.
dc.date.accessioned 2023-05-27T06:08:50Z
dc.date.available 2023-05-27T06:08:50Z
dc.date.issued 2009
dc.identifier.citation Biswajit Basu, Kevin Garala, Manojkumar Tyagi, G.L. Prabhushankar, P. R. Sathesh Babu. (2009). Formulation and In Vitro Evaluation of Periodontal Films Containing Metronidazole. Research Journal of Pharmaceutical Dosage Forms and Technology. 1(3): Nov. – Dec. 2009, 240-243, ISSN 0975-234X en_US
dc.identifier.issn 0975-234X
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1131
dc.description.abstract Local delivery devices are designed to deliver the drug locally into periodontal pocket. Metronidazole is a nitroimidazole used to treat protozoal infections. For local delivery, metronidazole films were prepared by solvent casting technique using ethyl cellulose, hydroxy propyl methylcellulose and eudragit RL-100 with dibutylphthalate and polyethylene glycol 400 as plasticizers. FTIR and UV spectroscopic methods revealed no interaction between metronidazole and polymers. The films were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, tensile strength, and surface pH. Data of in-vitro release from films were fit to different equations and kinetic models to explain release kinetics. Hixon-Crowell, Higuchi, and Korsmeyer-Peppas models were used to fit the in-vitro release data. Formulation F6 released 94.18% of drug at the end of 120 h, was considered as best formulation. Short-term stability study revealed that drug content decreased in various films was ranging from 1.361 to 2.209% en_US
dc.language.iso en en_US
dc.publisher Research Journal of Pharmaceutical Dosage Forms and Technology. en_US
dc.subject Metronidazole en_US
dc.subject periodontal pocket en_US
dc.subject periodontal films en_US
dc.subject local delivery en_US
dc.subject in-vitro release en_US
dc.title Formulation and In Vitro Evaluation of Periodontal Films Containing Metronidazole en_US
dc.type Article en_US


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