Abstract:
Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic
drug delivery. Pimozide patches were prepared using HPMC (15 & 47 cPs), carbopol 934, poly vinyl alcohol, and poly vinyl
pyrolidone. FTIR and UV spectroscopic methods revealed that there is no interaction between pimozide and polymers. The
patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling
behaviour, tensile strength, and surface pH. In vitro release studies of pimozide-loaded patches in phosphate buffer (pH,
6.6) exhibited drug release in the range of 55.32 % to 97.49 % in 60 min. Data of in vitro release from patches were fit in to
different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations,
Hixon-Crowell, Higuchi and Korsmeyer-Peppas models. In vivo absorption of pimozide from all the patches ranged from
47.96 % to 83.42 % in 60 min in human volunteers. In vivo studies in rabbits showed 85.97% of drug absorption from
HPMC-15 cPs patch in 60 min. Good correlation among in vitro release and in vivo absorption of pimozide was observed.
Description:
We are grateful to the Vasudha Pharma Chem Ltd,
Hyderabad, India for the gift sample of pimozide. We are
also grateful to Cadial Health Care Ltd, Ahmedabad, India
for the gift sample of carbopol and HPMC.