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Formulation and Evaluation of Pimozide Buccal Mucoadhesive Patches

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dc.contributor.author Basu, Biswajit
dc.contributor.author Garala, Kevin
dc.contributor.author Thimmasetty, J.
dc.date.accessioned 2023-05-27T06:33:46Z
dc.date.available 2023-05-27T06:33:46Z
dc.date.issued 2010-03
dc.identifier.citation Biswajit Basu, Kevin Garala, Thimmasetty J. (2010), Formulation and Evaluation of Pimozide Buccal Mucoadhesive Patches. International Journal of Pharmaceutical Sciences and Nanotechnology . Volume 2 Issue 4 ,ISSN : 0974-3278 en_US
dc.identifier.issn 0974-3278
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1133
dc.description We are grateful to the Vasudha Pharma Chem Ltd, Hyderabad, India for the gift sample of pimozide. We are also grateful to Cadial Health Care Ltd, Ahmedabad, India for the gift sample of carbopol and HPMC. en_US
dc.description.abstract Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. Pimozide patches were prepared using HPMC (15 & 47 cPs), carbopol 934, poly vinyl alcohol, and poly vinyl pyrolidone. FTIR and UV spectroscopic methods revealed that there is no interaction between pimozide and polymers. The patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, tensile strength, and surface pH. In vitro release studies of pimozide-loaded patches in phosphate buffer (pH, 6.6) exhibited drug release in the range of 55.32 % to 97.49 % in 60 min. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations, Hixon-Crowell, Higuchi and Korsmeyer-Peppas models. In vivo absorption of pimozide from all the patches ranged from 47.96 % to 83.42 % in 60 min in human volunteers. In vivo studies in rabbits showed 85.97% of drug absorption from HPMC-15 cPs patch in 60 min. Good correlation among in vitro release and in vivo absorption of pimozide was observed. en_US
dc.language.iso en en_US
dc.publisher International Journal of Pharmaceutical Sciences and Nanotechnology en_US
dc.subject Pimozide en_US
dc.subject buccal patches en_US
dc.subject in vitro release en_US
dc.subject in vivo absorption en_US
dc.subject evaluation en_US
dc.title Formulation and Evaluation of Pimozide Buccal Mucoadhesive Patches en_US
dc.type Article en_US


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