Abstract:
Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug
molecule by formulating a convenient dosage form for administration and to achieve better patient
compliance. One such approach is Rapid Disintegrating Tablets (RDT) which are those solid dosage
forms when put on tongue, disintegrate or dissolve instantaneously, releasing the drug, within a few
seconds without the need of water. RDT can be applicable in difficulty in swallowing (Dysphagia) or
chewing solid dosage forms to pediatrics, geriatrics, mentally ill, uncooperative and nauseated patients.
RDT is much more advantageous because of ease of administration, enhanced bioavailability, masking
the unpleasant taste of drug, etc. Many patented technologies have been developed such as Zydis,
Orasolv, Durasolv, WOWTAB, FlashDose, Nanocrystal technology etc. There are many conventional
techniques used in manufacturing of RDT such as direct compression, tablet moulding, freeze drying,
sublimation etc. RDT can be administered for large number of drugs. The prepared blend can be
evaluated for preformulation studies and the prepared tablets are then evaluated for quality control
tests. With the help of RDT, the objective of the patient compliance can be satisfactorily achieved.
