DSpace Repository

Development and Validation of A Rapid and Sensitive HPLC Method for Estimation of Racecadotril

Show simple item record

dc.contributor.author G., Kevin
dc.contributor.author Patel, J.
dc.contributor.author Dhingani, A.
dc.contributor.author Raval, M.
dc.contributor.author Dharamsi, A.
dc.date.accessioned 2023-05-27T07:20:06Z
dc.date.available 2023-05-27T07:20:06Z
dc.date.issued 2012
dc.identifier.citation Kevin G, Patel , Dhingani A, Raval M, Dharamsi A. Development and Validation of A Rapid and Sensitive HPLC Method for Estimation of Racecadotril. Inventi Rapid: Pharm Analysis & Quality Assurance, 2013(1):1-5, 2012. en_US
dc.identifier.issn 0976-3813
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1139
dc.description.abstract : A simple, specific, sensitive and rapid reverse phase high performance liquid chromatographic (HPLC) method for the determination of racecadotril (RCD) was developed and validated. Sample preparation involved simple dissolution, followed by dilution with mobile phase to eliminate any chromatographic solvent effects. RCD was quantitated on a C18 column (4.6 mm i.d. × 300 mm length), using a mobile phase composed of acetonitrile: water (65:35 %v/v) which was delivered at a flow rate of 1.0 mL/min. The method was proven to be linear over a concentration range of 5 to 100 μg/mL with a mean correlation coefficient of 0.9991. The intra-day and inter-day precision (coefficient of variation) were in the range of 0.53% to 0.92% and 0.95% to 1.76%, respectively. The intra-day accuracy (relative error) were in the range of 2.53% to 4.47% and the inter-day accuracy were in the range of 3.11% to 4.92%. The limit of detection (LOD) and the limit of quantification (LOQ) of the developed method were determined to be 0.5 μg/mL and 5 μg/mL, respectively. The developed method was established as a rapid analytical tool as it required short retention time, high precision, sensitivity and small volumes of sample for analysis en_US
dc.language.iso en en_US
dc.publisher Inventi Journals en_US
dc.title Development and Validation of A Rapid and Sensitive HPLC Method for Estimation of Racecadotril en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account