Abstract:
To overcome difficulty in swallowing tablets or capsules, scientists have considerably dedicated their effort to develop
novel drug delivery systems which enhance safety and efficacy of drug molecule and to achieve healthier patient compliance.
One such approach is mouth dissolving tablets (MDT). The purpose of this research was to mask the intensely unpleasant taste
of tramadol HCl by inclusion complexation, complexing with resin and solid dispersion to formulate mouth dissolving tablets of
the taste-masked drug. Tablets were formulated by wet granulation method using excipients. All formulations were evaluated
for dispersion time, wetting time, % friability, content uniformity and in-vitro dissolution rate. Formulations with Kyron T314
showed the least disintegration time and wetting time. In-vitro drug release study of taste masked tablet showed complete drug
release within 15 minutes and successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.
