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Formulation and Characterization of Taste Masked Mouth Dissolving Tablets of Tramadol HCl Using Different Approaches

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dc.contributor.author Garala, Kevin
dc.contributor.author Patel, Anjali
dc.contributor.author Rabara, Parag
dc.date.accessioned 2023-05-27T07:37:31Z
dc.date.available 2023-05-27T07:37:31Z
dc.date.issued 2016
dc.identifier.citation Kevin Garala, Anjali Patel, Parag Rabara. Formulation and Characterization of Taste Masked Mouth Dissolving Tablets of Tramadol HCl Using Different Approaches. Inventi Rapid: Pharm Tech, 2016(3):1-4, 2016. en_US
dc.identifier.issn 0976-3783
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1145
dc.description.abstract To overcome difficulty in swallowing tablets or capsules, scientists have considerably dedicated their effort to develop novel drug delivery systems which enhance safety and efficacy of drug molecule and to achieve healthier patient compliance. One such approach is mouth dissolving tablets (MDT). The purpose of this research was to mask the intensely unpleasant taste of tramadol HCl by inclusion complexation, complexing with resin and solid dispersion to formulate mouth dissolving tablets of the taste-masked drug. Tablets were formulated by wet granulation method using excipients. All formulations were evaluated for dispersion time, wetting time, % friability, content uniformity and in-vitro dissolution rate. Formulations with Kyron T314 showed the least disintegration time and wetting time. In-vitro drug release study of taste masked tablet showed complete drug release within 15 minutes and successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity. en_US
dc.language.iso en en_US
dc.publisher Inventi Journals en_US
dc.title Formulation and Characterization of Taste Masked Mouth Dissolving Tablets of Tramadol HCl Using Different Approaches en_US
dc.type Article en_US


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