dc.contributor.author |
Patel, Samixa |
|
dc.contributor.author |
Patel, Shweta |
|
dc.contributor.author |
Patel, Jignesh |
|
dc.contributor.author |
Patel, Paresh |
|
dc.date.accessioned |
2023-05-29T05:14:21Z |
|
dc.date.available |
2023-05-29T05:14:21Z |
|
dc.date.issued |
2011-01 |
|
dc.identifier.citation |
Patel, S. ,Patel, S. ,Patel, J. ,Patel, P. (2011).Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry. Research J. Pharm. and Tech. , 4(1) , Pages 109-112, ISSN 0974-3618 |
en_US |
dc.identifier.issn |
0974-3618 |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1148 |
|
dc.description |
The authors are greatly thankful to Torrent Research
Centre, Gujarat, India for providing gift samples of NEB
and AML and Shree S. K. Patel College of Pharmaceutical
Education and Research, Ganpat University, Kherva for
providing all the facilities to carry out the work. |
en_US |
dc.description.abstract |
Simple and accurate method to determine Nebivolol and Amlodipine, in tablet dosage form, was developed and
validated using Derivative Spectrophotometry. Derivative spectrophotometric method was based on the determination
of both the drugs at their respective zero crossing point (ZCP). The first-order derivative spectra were obtained at N =
1 (scaling factor), = 2.0 nm, and determination was performed at 226.5 nm (ZCP of Amlodipine) for Nebivolol and
245 nm (ZCP of Nebivolol) for Amlodipine over the concentration range of 10-70 g/mL for both drugs with mean
recovery of 100.2 ± 1.25 % and 100.1 ± 1.38 % for Nebivolol and Amlodipine, respectively. Method was validated,
and the results were compared statistically. They were found to be simple, sensitive, accurate, precise, reproducible
and economical. The method was successfully applied for the determination of Nebivolol and Amlodipine in tablet
dosage form without any interference from common excipients. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Research J. Pharm. and Tech. |
en_US |
dc.subject |
Nebivolol |
en_US |
dc.subject |
Amlodipine |
en_US |
dc.subject |
Derivative spectrophotometry |
en_US |
dc.subject |
zero crossing point |
en_US |
dc.title |
Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry |
en_US |
dc.type |
Article |
en_US |