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Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry

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dc.contributor.author Patel, Samixa
dc.contributor.author Patel, Shweta
dc.contributor.author Patel, Jignesh
dc.contributor.author Patel, Paresh
dc.date.accessioned 2023-05-29T05:14:21Z
dc.date.available 2023-05-29T05:14:21Z
dc.date.issued 2011-01
dc.identifier.citation Patel, S. ,Patel, S. ,Patel, J. ,Patel, P. (2011).Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry. Research J. Pharm. and Tech. , 4(1) , Pages 109-112, ISSN 0974-3618 en_US
dc.identifier.issn 0974-3618
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1148
dc.description The authors are greatly thankful to Torrent Research Centre, Gujarat, India for providing gift samples of NEB and AML and Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva for providing all the facilities to carry out the work. en_US
dc.description.abstract Simple and accurate method to determine Nebivolol and Amlodipine, in tablet dosage form, was developed and validated using Derivative Spectrophotometry. Derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first-order derivative spectra were obtained at N = 1 (scaling factor), = 2.0 nm, and determination was performed at 226.5 nm (ZCP of Amlodipine) for Nebivolol and 245 nm (ZCP of Nebivolol) for Amlodipine over the concentration range of 10-70 g/mL for both drugs with mean recovery of 100.2 ± 1.25 % and 100.1 ± 1.38 % for Nebivolol and Amlodipine, respectively. Method was validated, and the results were compared statistically. They were found to be simple, sensitive, accurate, precise, reproducible and economical. The method was successfully applied for the determination of Nebivolol and Amlodipine in tablet dosage form without any interference from common excipients. en_US
dc.language.iso en en_US
dc.publisher Research J. Pharm. and Tech. en_US
dc.subject Nebivolol en_US
dc.subject Amlodipine en_US
dc.subject Derivative spectrophotometry en_US
dc.subject zero crossing point en_US
dc.title Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry en_US
dc.type Article en_US


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