dc.contributor.author |
Patel, Samixa |
|
dc.contributor.author |
Patel, Chhaganbhai |
|
dc.date.accessioned |
2023-05-29T05:34:38Z |
|
dc.date.available |
2023-05-29T05:34:38Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
Samixa R Patel, Chhaganbhai N Patel. Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms. Asian J. Pharm. Ana. 2014; Vol. 4: Issue 4, Pg 166-171, ISSN- 2231–5667 ISSN- 2231–5675 (Online) |
en_US |
dc.identifier.issn |
2231–5675 |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1151 |
|
dc.description |
The authors are greatly thankful to Atmiya Institute of
Pharmacy, Yoghidham Gurukul for providing all the
facilities to carry out the work. |
en_US |
dc.description.abstract |
A simple, accurate, precise, economical and reproducible method was developed for simultaneous estimation of
aliskiren, amlodipine and hydrochlorothiazide in Combined Pharmaceutical Dosage Forms. The excipients in the
commercial tablet preparation did not interfere with the assay. The λmax for aliskiren, amlodipine and
hydrochlorothiazide were 252 nm, 360 nm and 271 nm respectively. At 360 nm, Amlodipine showed some absorbance
while aliskiren and hydrochlorothiazide showed zero absorbance so that amlodipine was estimated at 360 nm. While at
252 nm and 271 nm aliskiren and hydrochlorothiazide were determine by simultaneous estimation method after
eliminating the absorbent of Amlodipine at this wavelength. Linearity in concentration range of 4-28 μg/mL, 4-28
μg/mL and 20 - 120 μg/mL with The mean recoveries were 99.97 ± 0.82, 99.93 ± 0.88 and 100.14 ± 0.81 % for ALK,
AML and HTZ, respectively. Validation of the proposed method was carried out according to ICH guidelines. Thus
the present study gives an excellent method for the determination of all the three drugs in combined dosage
formulation without their prior separation |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Asian Pharma Press |
en_US |
dc.subject |
Amlodipine besylate |
en_US |
dc.subject |
hydrochlorothiazide |
en_US |
dc.subject |
Aliskiren |
en_US |
dc.subject |
Spectrophotometric method |
en_US |
dc.title |
Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms |
en_US |
dc.type |
Article |
en_US |