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Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms

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dc.contributor.author Patel, Samixa
dc.contributor.author Patel, Chhaganbhai
dc.date.accessioned 2023-05-29T05:34:38Z
dc.date.available 2023-05-29T05:34:38Z
dc.date.issued 2014
dc.identifier.citation Samixa R Patel, Chhaganbhai N Patel. Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms. Asian J. Pharm. Ana. 2014; Vol. 4: Issue 4, Pg 166-171, ISSN- 2231–5667 ISSN- 2231–5675 (Online) en_US
dc.identifier.issn 2231–5675
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1151
dc.description The authors are greatly thankful to Atmiya Institute of Pharmacy, Yoghidham Gurukul for providing all the facilities to carry out the work. en_US
dc.description.abstract A simple, accurate, precise, economical and reproducible method was developed for simultaneous estimation of aliskiren, amlodipine and hydrochlorothiazide in Combined Pharmaceutical Dosage Forms. The excipients in the commercial tablet preparation did not interfere with the assay. The λmax for aliskiren, amlodipine and hydrochlorothiazide were 252 nm, 360 nm and 271 nm respectively. At 360 nm, Amlodipine showed some absorbance while aliskiren and hydrochlorothiazide showed zero absorbance so that amlodipine was estimated at 360 nm. While at 252 nm and 271 nm aliskiren and hydrochlorothiazide were determine by simultaneous estimation method after eliminating the absorbent of Amlodipine at this wavelength. Linearity in concentration range of 4-28 μg/mL, 4-28 μg/mL and 20 - 120 μg/mL with The mean recoveries were 99.97 ± 0.82, 99.93 ± 0.88 and 100.14 ± 0.81 % for ALK, AML and HTZ, respectively. Validation of the proposed method was carried out according to ICH guidelines. Thus the present study gives an excellent method for the determination of all the three drugs in combined dosage formulation without their prior separation en_US
dc.language.iso en en_US
dc.publisher Asian Pharma Press en_US
dc.subject Amlodipine besylate en_US
dc.subject hydrochlorothiazide en_US
dc.subject Aliskiren en_US
dc.subject Spectrophotometric method en_US
dc.title Development and Validation of Spectrophotometric Method for Determination of Aliskiren, Amlodipine and Hydrochlorothiazide in combined Pharmaceutical Dosage Forms en_US
dc.type Article en_US


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