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RP-HPLC stability method development & validation for anti-HIV drugs cabotegravir & rilpivirine in I.M. injection and in human plasma

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dc.contributor.author Pandya, Yogi
dc.contributor.author Patel, Samixa
dc.date.accessioned 2023-05-29T05:46:24Z
dc.date.available 2023-05-29T05:46:24Z
dc.date.issued 2022
dc.identifier.citation Pandya, Y., & Patel, S. (2022). RP-HPLC stability method development & validation for anti-HIV drugs cabotegravir & rilpivirine in I.M. injection and in human plasma. International Journal of Health Sciences, 6(S1), 9104–9117. https://doi.org/10.53730/ijhs.v6nS1.7056 en_US
dc.identifier.issn 2550-696X
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1154
dc.description The authors favorably thank the contributors and co-workers in this research work, and under the guidance of Dr Samixa Patel without their support and acquaintance it would be a difficult task. The authors are also thankful to the industrial support from Bizotech life and Solisom pharma care for providing materials, chemicals, equipments and instrumentation facilities for the completion of the research. en_US
dc.description.abstract In Pharmaceutical & Medical Health Sciences there are necessities for development of analysis methods for medicines in various dosage forms. Currently the use of RP-HPLC is primarily applied for testing of medicines in various dosage forms, and to study bio analysis in human plasma matrix. The present method is developed for analysis of anti HIV drugs cabotegravir CAB and rilpivirine RILP in pure api & Intramuscular Injection dosage forms, and also in human plasma. The HPLC method is optimized for analysis of these two drugs in combined forms for swift analysis with very less amount of drugs utilized for testing purposes. The concentration range used for the linearity studies is 2.5 to 15µg/ml for CAB cabotegravir & for Rilpivirine RILP it is 3.75 to 22.5µg/ml. Wavelength selected for estimation is 242.5nm and column used was Kinetex C-18 column (250mm x 4.6mm, 5 µm id). The Retention-time obtained were 2.14min for CAB & 3.12min for RILP. The R2 was found to be 0.999 for both drugs. The method is applied for analysis of drugs in i.m. injections, individually & in combined forms. The Stability & forced-degradations studies were carried out in different stress conditions and the impurities & pure drugs, are efficiently detected by the developed HPLC method. en_US
dc.language.iso en en_US
dc.publisher International Journal of Health Sciences en_US
dc.subject RP-HPLC en_US
dc.subject Stability en_US
dc.subject Antiviral en_US
dc.subject HIV en_US
dc.subject Cabotegravir en_US
dc.subject Rilpivirine en_US
dc.subject I.M. Injection en_US
dc.subject Human Plasma en_US
dc.title RP-HPLC stability method development & validation for anti-HIV drugs cabotegravir & rilpivirine in I.M. injection and in human plasma en_US
dc.type Article en_US


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