Abstract:
The application of DSC technique has been employed for better understanding the behavior of multi-component
solid forms of poorly water-soluble drugs. Therefore, the purpose of the present work was to investigate the
binary system of Diacerein (DIC) by preparing multi-component adducts using various coformers. DIC and
different coformers were co-grounded with various solvents at 1:1, 2:1, and 1:2 M ratios. These solid forms were
characterized using DSC, PXRD, FT-IR, and SEM. DSC analysis preliminary characterized that aliphatic and
phenolic acid are competent enough to co-crystallize with DIC with lower melting endotherms via acetone
assisted grinding method. The results of PXRD, FT-IR, and SEM confirmed the formation of two novel eutectics of
DIC with fumaric acid (FUM) and 2, 4-dihydroxybenzoic (DIH) acid. Two eutectics, i.e., DIC-FUM (1:2) and DIC DIH (1:3) with exact stoichiometry were further identified by using Tamman’s triangle. The representative
samples were subjected to kinetic solubility measurements. Both the produced eutectics showed superior solubility compared to DIC alone with their stable nature. Hence, a low melting depression eutectic could be resolved
via DSC analysis applied as a diagnostic tool in designing the multi-component solid forms of the targeted drug
molecule.
Description:
These works has received funding from the Department of Science
and Technology, New Delhi, India providing DST-INSPIRE Fellowship
under approved letter number DST/INSPIRE Fellowship/2013/1079.