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Differential scanning calorimetry: A screening tool for the development of diacerein eutectics

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dc.contributor.author Patel, Rajeshri
dc.contributor.author Raval, Mihir
dc.date.accessioned 2023-05-29T06:11:18Z
dc.date.available 2023-05-29T06:11:18Z
dc.date.issued 2022
dc.identifier.citation Rajeshri D. Patel, Mihir K. Raval, Differential scanning calorimetry: A screening tool for the development of diacerein eutectics, Results in Chemistry, Volume 4, 2022, 100315, ISSN 2211-7156, https://doi.org/10.1016/j.rechem.2022.100315. en_US
dc.identifier.issn 2211-7156
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1157
dc.description These works has received funding from the Department of Science and Technology, New Delhi, India providing DST-INSPIRE Fellowship under approved letter number DST/INSPIRE Fellowship/2013/1079. en_US
dc.description.abstract The application of DSC technique has been employed for better understanding the behavior of multi-component solid forms of poorly water-soluble drugs. Therefore, the purpose of the present work was to investigate the binary system of Diacerein (DIC) by preparing multi-component adducts using various coformers. DIC and different coformers were co-grounded with various solvents at 1:1, 2:1, and 1:2 M ratios. These solid forms were characterized using DSC, PXRD, FT-IR, and SEM. DSC analysis preliminary characterized that aliphatic and phenolic acid are competent enough to co-crystallize with DIC with lower melting endotherms via acetone assisted grinding method. The results of PXRD, FT-IR, and SEM confirmed the formation of two novel eutectics of DIC with fumaric acid (FUM) and 2, 4-dihydroxybenzoic (DIH) acid. Two eutectics, i.e., DIC-FUM (1:2) and DIC DIH (1:3) with exact stoichiometry were further identified by using Tamman’s triangle. The representative samples were subjected to kinetic solubility measurements. Both the produced eutectics showed superior solubility compared to DIC alone with their stable nature. Hence, a low melting depression eutectic could be resolved via DSC analysis applied as a diagnostic tool in designing the multi-component solid forms of the targeted drug molecule. en_US
dc.language.iso en en_US
dc.publisher Resuls in Chemestry, Elsevier en_US
dc.subject Diacerein en_US
dc.subject Binary phase diagram en_US
dc.subject Eutectic en_US
dc.subject Kinetic solubility en_US
dc.subject Tamman’s triangle en_US
dc.title Differential scanning calorimetry: A screening tool for the development of diacerein eutectics en_US
dc.type Article en_US


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