dc.contributor.author |
Patel, Rajeshri |
|
dc.contributor.author |
Raval, Mihir |
|
dc.contributor.author |
Bagathariya, Ajrudeen |
|
dc.contributor.author |
Sheth, Navin |
|
dc.date.accessioned |
2023-05-29T06:16:35Z |
|
dc.date.available |
2023-05-29T06:16:35Z |
|
dc.date.issued |
2019 |
|
dc.identifier.citation |
Rajeshri D. Patel, Mihir K. Raval, Ajrudeen A. Bagathariya, Navin R. Sheth, Functionality improvement of Nimesulide by eutectic formation with nicotinamide: Exploration using temperature-composition phase diagram, Advanced Powder Technology, Volume 30, Issue 5, 2019, Pages 961-973, ISSN 0921-8831, https://doi.org/10.1016/j.apt.2019.02.010. |
en_US |
dc.identifier.issn |
0921-8831 |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1158 |
|
dc.description |
The author is very much grateful to Prof. (Dr.) Arvind Bansal,
Head, Department of Pharmaceutics, NIPER-Mohali and Prof. (Dr.)
Changquan Calvin Sun, Professor, Department of Pharmaceutics,
University of Minnesota, the USA for their continuous guidance
and support throughout the study. The author also acknowledges
Internal Quality Assurance Cell, Saurashtra University, Rajkot,
Gujarat (I) for their financial assistance in carrying out the study |
en_US |
dc.description.abstract |
The aim of present work was to explore the temperature-composition phase diagram for detection of for mation of a multi-component system. Fusion of model drug Nimesulide (NIM) and Nicotinamide (NIC)
was prepared and evaluated for possible interaction using thermal analysis. Phase diagram and the
appearance of single endotherm confirmed Eutectic formation with the molar ratio of 1:2 (NIM: NIC).
Spray dried powder in same molar ratio showed improved functionality in terms of solubility (14 folds),
dissolution (2 folds) in distilled water and drug content (92.27%). SEM study revealed that the particles of
eutectic mixture were of nearly same size in all directions in shape with bigger particle size compared to
the pure drug, which was responsible for its improved flow. The compressibility of prepared eutectic was
greatly enhanced which was followed by formation of directly compressible tablets. FT-IR study
explained the possibility of formation of hydrogen bond between both the components. Stability data
proved the stable nature of the eutectic mixture as well as its prepared formulation. The study explained
the way to prepare thermal phase diagram by taking solidus and liquidus points in DSC diagram, which
was finally used as a confirmatory parameter for the formation of the eutectic. Simultaneous improvement in physicochemical and mechanical properties was highlighted. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Advanced powder Technology, Elsevier |
en_US |
dc.subject |
Nimesulide |
en_US |
dc.subject |
Nicotinamide |
en_US |
dc.subject |
Eutectic |
en_US |
dc.subject |
Thermal-composition phase diagram |
en_US |
dc.subject |
Physico-mechanical property |
en_US |
dc.title |
Functionality improvement of Nimesulide by eutectic formation with nicotinamide: Exploration using temperature-composition phase diagram |
en_US |
dc.type |
Article |
en_US |