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Functionality improvement of Nimesulide by eutectic formation with nicotinamide: Exploration using temperature-composition phase diagram

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dc.contributor.author Patel, Rajeshri
dc.contributor.author Raval, Mihir
dc.contributor.author Bagathariya, Ajrudeen
dc.contributor.author Sheth, Navin
dc.date.accessioned 2023-05-29T06:16:35Z
dc.date.available 2023-05-29T06:16:35Z
dc.date.issued 2019
dc.identifier.citation Rajeshri D. Patel, Mihir K. Raval, Ajrudeen A. Bagathariya, Navin R. Sheth, Functionality improvement of Nimesulide by eutectic formation with nicotinamide: Exploration using temperature-composition phase diagram, Advanced Powder Technology, Volume 30, Issue 5, 2019, Pages 961-973, ISSN 0921-8831, https://doi.org/10.1016/j.apt.2019.02.010. en_US
dc.identifier.issn 0921-8831
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1158
dc.description The author is very much grateful to Prof. (Dr.) Arvind Bansal, Head, Department of Pharmaceutics, NIPER-Mohali and Prof. (Dr.) Changquan Calvin Sun, Professor, Department of Pharmaceutics, University of Minnesota, the USA for their continuous guidance and support throughout the study. The author also acknowledges Internal Quality Assurance Cell, Saurashtra University, Rajkot, Gujarat (I) for their financial assistance in carrying out the study en_US
dc.description.abstract The aim of present work was to explore the temperature-composition phase diagram for detection of for mation of a multi-component system. Fusion of model drug Nimesulide (NIM) and Nicotinamide (NIC) was prepared and evaluated for possible interaction using thermal analysis. Phase diagram and the appearance of single endotherm confirmed Eutectic formation with the molar ratio of 1:2 (NIM: NIC). Spray dried powder in same molar ratio showed improved functionality in terms of solubility (14 folds), dissolution (2 folds) in distilled water and drug content (92.27%). SEM study revealed that the particles of eutectic mixture were of nearly same size in all directions in shape with bigger particle size compared to the pure drug, which was responsible for its improved flow. The compressibility of prepared eutectic was greatly enhanced which was followed by formation of directly compressible tablets. FT-IR study explained the possibility of formation of hydrogen bond between both the components. Stability data proved the stable nature of the eutectic mixture as well as its prepared formulation. The study explained the way to prepare thermal phase diagram by taking solidus and liquidus points in DSC diagram, which was finally used as a confirmatory parameter for the formation of the eutectic. Simultaneous improvement in physicochemical and mechanical properties was highlighted. en_US
dc.language.iso en en_US
dc.publisher Advanced powder Technology, Elsevier en_US
dc.subject Nimesulide en_US
dc.subject Nicotinamide en_US
dc.subject Eutectic en_US
dc.subject Thermal-composition phase diagram en_US
dc.subject Physico-mechanical property en_US
dc.title Functionality improvement of Nimesulide by eutectic formation with nicotinamide: Exploration using temperature-composition phase diagram en_US
dc.type Article en_US


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