dc.contributor.author |
Patel, Rajeshri |
|
dc.contributor.author |
Raval, Mihir |
|
dc.contributor.author |
Pethani, Trupesh |
|
dc.contributor.author |
Sheth, Navin |
|
dc.date.accessioned |
2023-05-29T06:21:57Z |
|
dc.date.available |
2023-05-29T06:21:57Z |
|
dc.date.issued |
2020 |
|
dc.identifier.citation |
Rajeshri D. Patel, Mihir K. Raval, Trupesh M. Pethani, Navin R. Sheth, Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein, Advanced Powder Technology, Volume 31, Issue 4, 2020, Pages 1441-1456, ISSN 0921-8831, https://doi.org/10.1016/j.apt.2020.01.021. |
en_US |
dc.identifier.issn |
0921-8831 |
|
dc.identifier.uri |
http://10.9.150.37:8080/dspace//handle/atmiyauni/1159 |
|
dc.description |
The author gratefully acknowledges Department of Science and
Technology (DST), New Delhi, India, for providing DST-INSPIRE Fellowship to carry out this research work. Authors are grateful to
Prof. Arvind Bansal, Head, Department of Pharmaceutics, NIPER-Mohali, Prof. Changquan Calvin Sun, Professor, Department of
Pharmaceutics, University of Minnesota, USA and Mr. Dnyaneshwar Kale, PhD student, Department of Pharmaceutics, NIPER-Mohali, for their continuous guidance and support throughout
the study. |
en_US |
dc.description.abstract |
A multi-component system of diacerein (DIA) with 2, 4 – dihydroxybenzoic acid (DHA) as coformer at
various molar compositions was formulated to simultaneously improve solubility, compressibility and
bioavailability of DIA by applying acetone assistant grinding technique. Various evaluation parameters
pertaining to measure physicomechanical properties were conducted. Thermal analysis revealed a ‘V’-
shaped binary phase diagram along with single melting event as a possibility of eutectic formation
between drug and coformer. It was further confirmed PXRD and FT-IR. Equidimensional shape with platy
nature of eutectic material was observed in SEM images imparting its better flow and compressibility.
Solubility and dissolution study showed 2 and 1.8 folds enhancement respectively compared to pure
DIA and control batch. Pharmacokinetic study proved 2.1 times higher bioavailability in case of prepared
eutectic compared to DIA along with its stable nature. Hence, the multi-component system can become a
potential way for the improvement of material characteristics. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Advanced powder Technology, Elsevier |
en_US |
dc.subject |
Diacerein |
en_US |
dc.subject |
Eutectic |
en_US |
dc.subject |
Kinetic solubility |
en_US |
dc.subject |
Cocrystal |
en_US |
dc.subject |
Physico-mechanical |
en_US |
dc.subject |
Pharmacokinetic parameters |
en_US |
dc.title |
Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein |
en_US |
dc.type |
Article |
en_US |