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Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein

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dc.contributor.author Patel, Rajeshri
dc.contributor.author Raval, Mihir
dc.contributor.author Pethani, Trupesh
dc.contributor.author Sheth, Navin
dc.date.accessioned 2023-05-29T06:21:57Z
dc.date.available 2023-05-29T06:21:57Z
dc.date.issued 2020
dc.identifier.citation Rajeshri D. Patel, Mihir K. Raval, Trupesh M. Pethani, Navin R. Sheth, Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein, Advanced Powder Technology, Volume 31, Issue 4, 2020, Pages 1441-1456, ISSN 0921-8831, https://doi.org/10.1016/j.apt.2020.01.021. en_US
dc.identifier.issn 0921-8831
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/1159
dc.description The author gratefully acknowledges Department of Science and Technology (DST), New Delhi, India, for providing DST-INSPIRE Fellowship to carry out this research work. Authors are grateful to Prof. Arvind Bansal, Head, Department of Pharmaceutics, NIPER-Mohali, Prof. Changquan Calvin Sun, Professor, Department of Pharmaceutics, University of Minnesota, USA and Mr. Dnyaneshwar Kale, PhD student, Department of Pharmaceutics, NIPER-Mohali, for their continuous guidance and support throughout the study. en_US
dc.description.abstract A multi-component system of diacerein (DIA) with 2, 4 – dihydroxybenzoic acid (DHA) as coformer at various molar compositions was formulated to simultaneously improve solubility, compressibility and bioavailability of DIA by applying acetone assistant grinding technique. Various evaluation parameters pertaining to measure physicomechanical properties were conducted. Thermal analysis revealed a ‘V’- shaped binary phase diagram along with single melting event as a possibility of eutectic formation between drug and coformer. It was further confirmed PXRD and FT-IR. Equidimensional shape with platy nature of eutectic material was observed in SEM images imparting its better flow and compressibility. Solubility and dissolution study showed 2 and 1.8 folds enhancement respectively compared to pure DIA and control batch. Pharmacokinetic study proved 2.1 times higher bioavailability in case of prepared eutectic compared to DIA along with its stable nature. Hence, the multi-component system can become a potential way for the improvement of material characteristics. en_US
dc.language.iso en en_US
dc.publisher Advanced powder Technology, Elsevier en_US
dc.subject Diacerein en_US
dc.subject Eutectic en_US
dc.subject Kinetic solubility en_US
dc.subject Cocrystal en_US
dc.subject Physico-mechanical en_US
dc.subject Pharmacokinetic parameters en_US
dc.title Influence of eutectic mixture as a multi-component system in the improvement of physicomechanical and pharmacokinetic properties of diacerein en_US
dc.type Article en_US


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