Abstract:
River is one of the main biological resources and has potential to solve threat caused
by antimicrobial resistance. From different river water sample and soil sample of Uttarakhand,
India the microbes were isolated and screened to check it’s antimicrobial activities. The
objective was to identified potential antibacterial from river sources which may help in
treatment of antimicrobial resistance. The antimicrobial activity of isolates was checked against
two pathogens: Salmonella typhi and Acinetobacter baumannii. Preliminary screening of river
microorganism in opposition to antibiotic resistant pathogen is performed by cross streak
technique. Secondary screening of positive isolates is done using Agar well diffusion
technique, in addition a comparison was also made between centrifuged and non-centrifuged
isolates to check whether the antimicrobial substance is produced externally or internally. A
zone-of-inhibition was found in non-centrifuged plates around two isolates. Thus, further
research on river bodies may lead to find better treatment of antimicrobial resistance.
