Abstract:
One of the major problems of causes of death worldwide is cardiovascular
disease, according to the American heart association. An unwanted blood clot (thrombi) is
caused by dysregulation in the blood clotting system caused by abnormalities in the blood that
provoke thrombosis and lead to heart attack, strokes, blocking of blood vessels and coronary
artery disease etc. An Increasing percentage of deaths due to thrombosis. Commonly treat
thrombosis different thrombolysis agents are used. A huge potential has a thrombolytic agent
and it plays a major role. The fibrinolytic enzyme is considered a potent thrombolytic agent to
treat and prevent cardiovascular diseases (CVDs). The commercially available thrombolytic
agents such as Urokinase plasminogen activator, Streptokinase plasminogen activator and
tissue plasminogen activator are generally safe but are very expensive and are less effective.
Thrombolytic agents are of two types, one is plasmin like proteins which directly degrade fibrin
and another one is plasminogen activator which activates plasminogen into active plasmin to
degrade fibrin. The molecular weights of the proteins that play roles in the fibrinolytic activity
ranged from approximately 30 to 153 kDa. The health benefits of some fermented foods are a
synthesis of nutrients, prevention of cancer and cardiovascular disease due to the presence of
functional microorganisms, which possess probiotics properties and anticoagulant. The
fermented foods as sources of microorganism used were Rice water, Dhokla, Idli water. The
total positive number of isolates were 27, out of which only 7 had significant proteolytic
activity for fibrinolysis.
