Abstract:
Cancer is defined as the unchecked expansion of aberrant cells. Radiation,
chemotherapy, and surgery are currently used in combination to treat cancer. Traditional
drug delivery techniques kill healthy proliferating cells when used over prolonged periods
of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do
not infiltrate right away, this is particularly true when treating solid tumors. A targeted
drug delivery system (TDDS) is a tool that distributes medication to a selected bioactive
location in a controlled manner. Nanotechnology-based delivery techniques are having a
substantial impact on cancer treatment, and polymers are essential for making nanoparticulate
carriers for cancer therapy. The advantages of nanotherapeutic drug delivery systems
(NDDS) in terms of technology include longer half-life, improved biodistribution,
longer drug circulation time, regulated and sustained drug release, flexibility in drug administration
method, higher drug intercellular concentration, and others. The benefits
and drawbacks of cancer nanomedicines, such as polymer-drug conjugates, micelles,
dendrimers, immunoconjugates, liposomes, and nanoparticles, are discussed in this
work, along with the most recent findings on polymer-based anticancer drugs.
