Abstract:
In recent years, due to their distinctive and adaptable therapeutic effects, many natural
bioactive compounds have been commonly used to treat diseases. Their limited solubility, low
bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of
action limited their pharmaceutical applications. However, those can be improved using nanotechnology
to create various drug delivery systems, including lipid-based nanoparticles, to adjust the
compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical
advancements made in the fundamental sciences and the physical and chemical manipulation
of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary
growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon
in research and development for overcoming restrictions, including traditional medication administration
systems. Nanotechnology-driven bioactive compounds are certain to have a high impact
and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver
a range of naturally occurring bioactive compounds with decent entrapment potential and stability,
a successfully controlled release, increased bioavailability, and intriguing therapeutic activity.
This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin,
kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a
natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation
and clinical considerations.
