Abstract:
The objective of the study was to formulate ketorolac tromethamine, a non-steroidal
anti-inflammatory drug, into a sustained-release tablet. Using the wet granulation
method, tamarind gum, tapioca starch, and chitosan, as well as their individual and
combined polymers, were used to create sustain-release matrix tablets containing
ketorolac tromethamine. UV spectroscopy was used for the identification of drugs, and
FTIR and DSC were used for compatibility studies. Pre- and post-compression
parameters were performed as part of the evaluation process. The dissolution aperture
was used for the in-vitro drug release investigations. Kinetic analysis was performed on
the optimized formulation's in-vitro drug release data. A stability analysis of the KT12
optimized formulation was conducted. The formulation KT12, which combines chitosan
and tamarind gum, demonstrated the highest drug release (99.89%) after 24 hours. It
was evident from the release statistics and swelling properties that the formulation KT12
had the best sustaining capabilities. According to stability studies, formulation KT12
exhibits physical stability. Thus, it was determined that a mixture of polymers (chitosan
and tamarind gum) was effective in producing ketorolac tromethamine sustain-release
matrix tablets, which delay drug release for up to 24 hours.
