Formulation and Evaluation of Sustain Release Matrix Based Tablet of Ketorolac Tromethamine Using Tamarind Gum and Tapioca Starch Natural Polymers As Release Modifiers

Abstract

The objective of the study was to formulate ketorolac tromethamine, a non-steroidal anti-inflammatory drug, into a sustained-release tablet. Using the wet granulation method, tamarind gum, tapioca starch, and chitosan, as well as their individual and combined polymers, were used to create sustain-release matrix tablets containing ketorolac tromethamine. UV spectroscopy was used for the identification of drugs, and FTIR and DSC were used for compatibility studies. Pre- and post-compression parameters were performed as part of the evaluation process. The dissolution aperture was used for the in-vitro drug release investigations. Kinetic analysis was performed on the optimized formulation's in-vitro drug release data. A stability analysis of the KT12 optimized formulation was conducted. The formulation KT12, which combines chitosan and tamarind gum, demonstrated the highest drug release (99.89%) after 24 hours. It was evident from the release statistics and swelling properties that the formulation KT12 had the best sustaining capabilities. According to stability studies, formulation KT12 exhibits physical stability. Thus, it was determined that a mixture of polymers (chitosan and tamarind gum) was effective in producing ketorolac tromethamine sustain-release matrix tablets, which delay drug release for up to 24 hours.