Abstract:
Psoriasis is a chronic autoimmune skin disease
with a worldwide prevalence of 1–3 % results from uncontrolled
proliferation of keratinocytes and affects millions of
people. While there are various treatment options available,
some of them may come with potential side effects and
limitations. Recent research has shown that using bioactive
compounds that originate from natural sources with a lower
risk of side effects are relatively useful in safe management
psoriasis. Bioactive compounds are molecules that are
naturally available with potential therapeutic efficacy.
Some of bioactive compounds that have shown promising
results in the management of psoriasis include curcumin,
resveratrol, quercetin, epigallocatechin-3-gallate, etc.,
possess anti-inflammatory, antioxidant, immunomodulatory,
and anti-proliferative properties, with capabilities to
suppress overall pathogenesis of psoriasis. Moreover, these
bioactive compounds are generally considered as safe
and are well-tolerated, making them potential options for
long-term use in the management of various conditions
linked with psoriasis. In addition, these natural products
may also offer a more holistic approach to treat the disease,
which is appealing to many patients. This review explores
the bioactive compounds in mitigation of psoriasis either
in native or incorporated within novel drug delivery.
Moreover, recent clinical findings in relation to natural
product usage have been also explored.
