Abstract:
Tamoxifen (TAM), a non-steroidal antiestrogen, has revolutionized female
breast cancer treatment. The mechanism involves is to compete with
17β-estradiol (E2) at the receptor site and blocking the promotional role of
E2 in breast cancer. Tam is a pioneering medicine because of its widespread
usage in breast cancer treatment and chemoprevention, as well as
research into novel selective estrogen receptor modulators (SERMs). In
the vast majority of patients, TAM is cost-effective, life-saving, and free
of significant adverse effects. In this context, this review presents several
nanoformulations for selectively delivered lower dosages of TAM to breast
tumors. Various TAM-containing nanosystems have been effectively created
to deliver TAM to particular molecular targets with decreasing harmful
effects. Following that, there is a summary of chromatographic techniquesto quantify the drug in human biological samples. The quantification of the
drug in different biological matrices is the major importance to assist the
control of quality, efficacy, and safety.
