A Short Review on Analysis of Itraconazole in Bulk Drug and in Pharmaceutical Dosage Form

Abstract

Itraconazole (ITZ) is an antifungal triazole, used to treat systemic and superficial fungal infections. Its clinical effectiveness is limited due to its low water solubility which results in poor bioavailability. Therefore, there is a need to develop a trailblazer formulation capable to enhance solubility, dissolution and bioabsorption of ITZ for better topical and systemic use. In context to this, this review represents the summary of physicochemical characteristics, various nano dosage forms and analytical methods utilized for ITZ. The quantifications of ITZ have already been published in various kind of literature with a special focus on UV-Vis spectrophotometric, spectrofluorometric, HPLC and other hyphenated techniques. Numerous parameters like λmax, solvents, stationary phase, mobile phase, retention time, column have been demonstrated. This concise report reveals all the analytical methods already used with its important parameters for the estimation of ITZ that will benefit researchers and contribute to the existence in this area.