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Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form
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| dc.contributor.author | Shah, Pranavkumar | |
| dc.contributor.author | Hadiyal, Sanjay | |
| dc.contributor.author | Lalpara, Jaydeep | |
| dc.contributor.author | Dubal, Gaurang | |
| dc.contributor.author | Dhaduk, Bhavin | |
| dc.date.accessioned | 2024-11-19T06:12:53Z | |
| dc.date.available | 2024-11-19T06:12:53Z | |
| dc.date.issued | 2024 | |
| dc.identifier.citation | Shah, P., Hadiyal, S., Lalpara, J., Dubal, G., & Dhaduk, B. (2024). Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form. Pharmaceutical Chemistry Journal, 57(10), 1674-1682. | en_US |
| dc.identifier.uri | http://10.9.150.37:8080/dspace//handle/atmiyauni/1671 | |
| dc.description.abstract | A suitable RP-UPLC method for the quantitative analysis of degradation impurities of Benidipine hydrochloride & Metoprolol succinate is reported. The method was validated for specicity, linearity, range, accuracy, precision, sensitivity (LOQ and LOD), and robustness. The method shows excellent linearity with linear regression (r > 0.9950) within concentration range (0.5 to 3.0 μg/mL). LOD values were 0.14, 0.16 and, 0.15 and LOQ values were 0.42, 0.49 and 0.45 μg/mL for MET impurity-B & O and BEN impurity-2, respectively. The proposed method could be applied to routine quality control analysis | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Springer / Pharmaceutical Chemistry Journal | en_US |
| dc.relation.ispartofseries | ;57(10), 1674-1682 | |
| dc.subject | RP-UPLC Method | en_US |
| dc.subject | Quantitative Determination | en_US |
| dc.subject | Degradation Impurities | en_US |
| dc.subject | Benidipine Hydrochloride | en_US |
| dc.subject | Metoprolol Succinate | en_US |
| dc.subject | Combined Dosage | en_US |
| dc.subject | Stability | en_US |
| dc.title | Stability Indicating RP-UPLC Method for the Quantitative Determination of Degradation Impurities of Benidipine Hydrochloride & Metoprolol Succinate in Combined Dosage Form | en_US |
| dc.type | Article | en_US |
