Abstract:
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction between the free reducing sugars
and proteins, lipids, or nucleic acids. AGEs are predominantly synthesized during chronic hyperglycemic conditions or
aging. AGEs interact with their receptor RAGE and activate various sets of genes and proteins of the signal transduction
pathway. Accumulation of AGEs and upregulated expression of RAGE is associated with various pathological conditions
including diabetes, cardiovascular diseases, neurodegenerative disorders, and cancer. The role of AGE-RAGE signaling has
been demonstrated in the progression of various types of cancer and other pathological disorders. The expression of RAGE
increases manifold during cancer progression. The activation of AGE-RAGE signaling also perturbs the cellular redox balance
and modulates various cell death pathways. The programmed cell death signaling often altered during the progression
of malignancies. The cellular reprogramming of AGE-RAGE signaling with cell death machinery during tumorigenesis is
interesting to understand the complex signaling mechanism of cancer cells. The present review focus on multiple molecular
paradigms relevant to cell death particularly Apoptosis, Autophagy, and Necroptosis that are considerably influenced by the
AGE-RAGE signaling in the cancer cells. Furthermore, the review also attempts to shed light on the provenience of AGERAGE
signaling on oxidative stress and consequences of cell survival mechanism of cancer cells
