DSpace Repository

AGE‑RAGE synergy influences programmed cell death signaling to promote cancer

Show simple item record

dc.contributor.author Waghela, Bhargav N
dc.contributor.author Vaidya, Foram U
dc.contributor.author Kishu Ranjan, Tiwari
dc.contributor.author Abu Sufiyan Chhipa, Budhi Sagar
dc.date.accessioned 2024-11-25T10:24:31Z
dc.date.available 2024-11-25T10:24:31Z
dc.date.issued 2020
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/2028
dc.description.abstract Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are predominantly synthesized during chronic hyperglycemic conditions or aging. AGEs interact with their receptor RAGE and activate various sets of genes and proteins of the signal transduction pathway. Accumulation of AGEs and upregulated expression of RAGE is associated with various pathological conditions including diabetes, cardiovascular diseases, neurodegenerative disorders, and cancer. The role of AGE-RAGE signaling has been demonstrated in the progression of various types of cancer and other pathological disorders. The expression of RAGE increases manifold during cancer progression. The activation of AGE-RAGE signaling also perturbs the cellular redox balance and modulates various cell death pathways. The programmed cell death signaling often altered during the progression of malignancies. The cellular reprogramming of AGE-RAGE signaling with cell death machinery during tumorigenesis is interesting to understand the complex signaling mechanism of cancer cells. The present review focus on multiple molecular paradigms relevant to cell death particularly Apoptosis, Autophagy, and Necroptosis that are considerably influenced by the AGE-RAGE signaling in the cancer cells. Furthermore, the review also attempts to shed light on the provenience of AGERAGE signaling on oxidative stress and consequences of cell survival mechanism of cancer cells en_US
dc.language.iso en en_US
dc.subject Cell death en_US
dc.subject AGE-RAGE signaling en_US
dc.subject Cancer en_US
dc.title AGE‑RAGE synergy influences programmed cell death signaling to promote cancer en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account