Abstract:
Novel hybrid molecules of thiazolopyrimidine
4a–j
have been prepared starting fromvarious thiazoles
3a–j
. The reaction of thiazoles
3a–j
with thiourea yielded hybridmolecules
4a–j
in an excellent yield. These molecules were screened for their anticanceractivities against human breast carcinoma cell line (MCF-7), human lungadenocarcinoma cell line (A549) and human cervical cancer cell line (HeLa) using MTTassay. Among all molecules, compounds
4g
and
4f
exhibited potent cytotoxic activity.Compound
4g
with IC
value of 3.1 ± 0.4 μM and IC
value of 9.8 ± 0.4 μM against A549and HeLa cell line, respectively. Compound
4f
with IC
value of 6.8 ± 0.7 μM against MCF-7 molecular docking study of all synthesized molecules
4a–j
was performed on
