Abstract:
In this work, pyrazole based oxothiazolidine hybrids, 4-{4-[2-(1-
phenyl-3-(substituted)phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3-
yl]-phenyl}-morpholin-3-one (11a-l) were synthesized using molecular
hybridization approach through Vilsmeier-Haack reaction. The titled
compounds 11a-l were characterized by using elemental analysis, IR,
1H NMR and mass spectral studies. The antibacterial activity of 11a-l
was evaluated in vitro by agar cup plate method against B. cocous, B.
subtillis, E. coli and P. vulgaris. The antifungal activity of compounds
11a-l was evaluated in vitro by agar based disk diffusion method
against A. niger. The results of antibacterial and antifungal evaluation
were reported in terms of zone of inhibition measured in mm. The
synthesized compounds 11a-l exhibited moderate to good antibacterial
and antifungal potential. Compound 4-{4-[2-(1-phenyl-3-(2-methoxyphenyl)
phenyl-1H-pyrazol-4-yl)-4-oxo-thiazolidin-3-yl]-phenyl}-
morpholin-3-one (11h) emerged as a most potent antimicrobial agent
displaying zone of inhibition 21, 20, 21, 24 and 20 mm against B.
cocous, B. subtillis, E. coli, P. vulgaris and A. niger, respectively.
