00. Faculty Publications: Recent submissions

Now showing items 121-140 of 159

High‑performance thin‑layer chromatography‒spectrodensitometric determination of diltiazem hydrochloride and its commonly occurring degradation impurity

Varu, H. L; Nariya, P. B; Patel, A. S; Gadher, M; Makhasana, M.; Lunagariya, K.; Ambasana, M. A. (Journal of Planar Chromatography, 2024)

The present work encompassed the assay quantification of diltiazem hydrochloride and its degradation impurity F by high-performance thin-layer chromatography (HPTLC). HPTLC was performed with chloroform‒methanol‒formic ...
An efficient synthesis of novel isoxazole bearing pyrazole derivatives via [3+ 2] heteroannulation using cupric acetate

Audichya, Vipul B.; Savant, Mahesh M.; Naliapara, Yogesh T. (Wiley/ Journal of Heterocyclic Chemistry, 2022)

The synthesis of novel 3-(4,5-dichloro-2-fluorophenyl)-1-phenyl-4-(3-phenylisoxazol-5-yl)-1H-pyrazole(7a–p) has been achieved via [3 + 2] heteroannulation reaction 3-(3-[4,5-dichloro-2-fluorophenyl]-1-phenyl-1H-pyrazol-4 ...
Synthesis, anticancer evaluation and in silico studies of novel N-substituted arylidenethiazolidine-2,4-dione derivatives as adenosine monophosphate-activated protein kinase activators

Chothani, S. R.; Chamakiya, C. A.; Joshi, R. J.; Karmur, M. B.; Karmur, S. B.; Varu, H. L.; Kapuriya, N. P. (Journal of Heterocyclic Chemistry, 2024)

Design and development of AMP‐activated protein kinase (AMPK) activator emerged as a potential therapeutic approach for various types of cancers. In this context, thiazolidine 2,4‐dione was invariably found as an important ...
Synthesis, Spectroscopic and In-Vitro Antimicrobial Screening of Some Novel Transition Metal Based Heterochelates

Gajera, Prashant; Vadodaria, Milan; Raja, Maulik; Cholera, Archana (IJBPAS, 2023-12-01)

New Mn(II), Cu(II) and Zn(II) heterochelates were synthesize by reacting Semicarbazone, Thiosemicarbazone and Antipyrine with 2 amino 3,5 dibromo benzaldehyde. All the synthesized Schiff’s base ligands and their heterochelates ...
Correlation study between “structure and commencement temperature” of nematogenic mesomorphs having Azo-Ester linkage

Baku, Neha K.; Cholera, Archana Y.; Travadi, J. J. (World Scientific News, 2023)

Correlation study between ‘commencement of Nematic Transition Temperature (NTT)’ and their ‘structural property data set’ is carry out. Stepwise backward regression analysis method is applied to find out good correlation ...
Design, Synthesis and Antidiabetic Activity of Biphenylcarbonitrile‐Thiazolidinedione Conjugates as Potential α‐Amylase Inhibitors.

Rathod, C. H.; Nariya, P. B.; Maliwal, D.Pissurlenkar; Kapuriya, R. R.; Patel, A. S. (ChemistrySelect, 2021)

Abstract The α‐amylase inhibition has been considered as an effective therapeutic approach against chronic Type 2 Diabetes mellitus (DM). In the present study, a series of biphenylcarbonitrile‐thiazolidinedione conjugates ...
From catalysis to combat: calix[4]pyrrole‑wreathed palladium nanoparticles as ambidextrous tools against cancer and tuberculosis

Pomal, N. C.; Bhatt, K. D; Patel, A. S.; Dholariya, M. P.; Kundariya, D. S; Parikh, J. (Applied Nanoscience, 2023)

Palladium nanoparticles (PdNPs) have gained significant importance due to its prodigious properties and applications. To harness the multifaceted applications of PdNPs, we report a facile synthesis of calix[4]pyrrole ...
Solvent-free synthesis, biological evaluation and in silico studies of novel 2-amino-7-(bis (2-hydroxyethyl)amino)-4H-chromene-3-carbonitrile derivatives as potential a-amylase inhibitors

Chothani, S. R; Dholariya, M. P.; Joshi, R. J.; Chamakiya, C. A.; Maliwal, D.; Pissurlenkar, R. R.; Kapuriya, N. P. (Journal of Molecular Structure, 2023)

Despite a wide range of kinase inhibitory activities exhibited by 2-amino-4H-chromenes, their potential appli- cation towards α-amylase inhibition remained rarely explored to date. For that purpose, a series of new 2-amino- ...
Synthesis, In Vitro Antimicrobial Evaluation, ADMET Properties, and Molecular Docking Studies of Novel Thiazole Derivatives

Jatiyaa, J. N.; Patela, A. S.; Savanta, M. M. (Pleiades Publishing, Ltd., 2023)

A series of novel ethyl (Z)-2-cyano-3-[(4-methyl-5-{2-[(Z)-1-arylethylidene]hydrazine-1-carbonyl}- thiazol-2-yl)amino]-3-(methylthio)acrylate derivatives was synthesized through four step method. The process generates novel ...
Design and synthesis of 1, 2-bis (hydroxymethyl) pyrrolo [2, 1-a] phthalazine hybrids as potent anticancer agents that inhibit angiogenesis and induce DNA interstrand cross-links.

Jain, S. M.; Chen, T. L; Patel, A. S; Pidugu, H. B.; Lin, Y. W.; Lee, T. C. (ACS Publications, 2019)

Hybrid molecules are composed of two pharmacophores with different biological activities. Here, we conjugated phthalazine moieties (antiangiogenetic pharmacophore) and bis(hydroxymethyl)pyrrole moieties (DNA cross-linking ...
Synthesis of Substituted 4-(4-((3-Nitro-2-oxo-2H-chromene-4- yl)amino)phenyl)morpholine-3-one Coumarin Derivatives

SANGHANI, YOGESH J.; KORADIYA, SURESH B.; PATEL, ANILKUMAR S. (Asian Journal of Chemistry, 2019)

In the large family of heterocyclic chemistry, coumarin and its derivatives have significant role due to their distinct applications, abundant availability in nature and various routes for its synthesis. The main aim of ...
Design, Synthesis and Antidiabetic Activity of Biphenylcarbonitrile-Thiazolidinedione Conjugates as Potential α-Amylase Inhibitors

Rathod, Chirag H; Nariya, Pankajkumar B.; Maliwal, Deepika; Pissurlenkar, Raghuvir RS; Kapuriya, Naval P.; Patel, Anilkumar S (2021-02-24)

The á-amylase inhibition has been considered as an effective therapeutic approach against chronic Type 2 Diabetes mellitus (DM). In the present study, a series of biphenylcarbonitrilethiazolidinedione conjugates have ...
Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water

Patel, A. S.,; Gandhi, S. A; Modh, R. D; Patel, U. H.,; Naliapara, Y. T; Kapuriya, N. P (Bentham Science Publishers, 2021)

An inexpensive and eco-friendly Wittig olefination protocol has been developed to pre-pare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent ...
Steroid and Fatty Acid Contents from the Leaves of Carica Papaya

Devmurari, Vishvraj V.; Patel, Poojaben P; Jadeja, Rajeshreeba A; Bhadaniya, Cameykumari P; Aghara, Priti P; Patel, Anilkumar S; Tala, Satishkumar D; Savant, Mahesh M; Ladva, Kartik D; . Nariya, Pankajkumar B (2021-06-30)

Aim: To extract and identify the non-polar entities from the leaves of Carica papaya, a plant used for medicinal purpose as folk medicine. Materials and methods: Petroleum ether extract of the Carica papaya leaves was used ...
Ameliorative effects of Triphala on mucosal damage in rat model of ulcerative colitis

Nariya, Mukeshkumar; Nariya, Pankaj; Ravishankara, Basavaiah; Goswami, Sunita (2021-04-19)

In Ayurvedic practice, Triphala is widely used in gastric problems including constipation, large intestinal inflammation and colitis. The present research was planned to assess the ameliorative effects of Triphala ...
Synthesis of Pyrrole Derivatives via Cycloaddition Reaction of Reissert Hydrofluoroborate Salts with α-Bromoacrylamides

Rathod, Chirag H.; Patel, Anilkumar S. (Analytical Chemistry Letters, 2021)

Abstract An investigation of α-bromoacrylamide as a dienophile for the cycloaddition reaction of Reissert hydrofluoroborate salt of quinoline/phenanthridine has been carried out. The optimized condition has been developed ...
Steroid and Fatty Acid Contents from the Leaves of Carica Papaya

Devmurari, Vishvraj.V.; Patel, Poojaben P.; Jadeja, Rajeshreeba A.; . Bhadaniya, Cameykumari P.; Nariya, Pankajkumar B. (Folia Medica, 2021)

Aim: To extract and identify the non-polar entities from the leaves of Carica papaya, a plant used for medicinal purpose as folk medi-cine. Materials and methods: Petroleum ether extract of the Carica papaya leaves was ...
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links

Chen, TL; Patel, AS; Jain, V; Kuppusamy, R; Lin, YW; Hou, MH; Su, TL; Lee, TC (ACS Publications, 2021)

Designing hybrid molecules with dual functions is one approach to improve the therapeutic efficacy of combination treatment. We have previously conjugated phthalazine and bis- (hydroxymethyl)pyrrole pharmacophores to form ...
Rapid Identification of Fatty Acids from Leptadenia reticulata Areal Parts byGC-MS

Dhalani, Jayesh; Parmar, Rahul; Rajpara, Raj; Nariya, Pankajkumar (2020-05-20)

The investigation was carried out to identify the various fatty acids present in the areal parts of Leptadenia reticulata, one of the important medicinal plants of India. Non-polar (Petroleum Ether) extract of areal parts ...
Design, synthesis and antitumour evaluation of pyrrolo [1, 2-f]-phenanthridine and dibenzo [f, h] pyrrolo [1, 2-b] isoquinoline derivatives

Patel, A.S.; Jain, V; Rao, V.N.; Lin, Y.W.; Shah, A; Lai, K.C.; Su, T.L.; Lee, TC (European Journal of Medicinal Chemistry, 2020)

Abstract A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates and 12,13-bis(hydroxymethyl)-9,14-dihydro-dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives ...

Now showing items 121-140 of 159

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