00. Faculty Publications: Recent submissions

Now showing items 81-100 of 111

Formulation and in-vitro characterization of monolithic matrix Transdermal systems using hpmc/eudragit s 100 polymer blends

Garala, Kevin; Shinde, Anil; Shah, Pratik (International Journal of Pharmacy and Pharmaceutical Sciences, 2009-12)

In the present work, monolithic matrix transdermal systems containing tramadol HCl were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl ...
Solubility of aceclofenac in polyamidoamine dendrimer solutions

Patel, Jaydeep; Garala, Kevin; Basu, Biswajit; Raval, Mihir; Dharamsi, Abhay (International Journal of Pharmaceutical Investigation, 2011-07)

In the present study we investigated the effect of polyamidoamine (PAMAM) dendrimers on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimers in distilled ...
Influence of excipients and processing conditions on the development of agglomerates of racecadotril by crystallo‑co‑agglomeration

Garala, Kevin; Patel, Jaydeep; Patel, Anjali; Raval, Mihir; Dharamsi, Abhay (International Journal of Pharmaceutical Investigation, 2012-12)

Purpose: The purpose of the present investigation was to improve the flow and mechanical properties of racecadotril by a crystallo‑co‑agglomeration (CCA) technique. Direct tableting is a requirement of pharmaceutical ...
Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery

Patel, Jaydeep; Garala, Kevin; Patel, Anjali; Raval, Mihir; Sheth, Navin (International Journal of Pharmaceutical Investigation (Medknow Publications), 2011-04)

Background and Aim: Telmisartan (TEL) is an angiotensin II receptor blocker (ARB) antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance ...
Functionality improvement of Chlorzoxazone by crystallo-co-agglomeration using multivariate analysis approach

Raval, Mihir; Garala, Kevin; Patel, Jaydeep; Parikh, Rajesh; Sheth, Navin (Particulate Science and Technology An International Journal (Taylor & Francis Online), 2020-07)

The aim of present work was to improve physicochemical properties of model drug Chlorzoxazone by crystallo-co-agglomeration (CCA) in the presence of different polymers and excipients. Identification of Quality Target ...
Pharmaceutical Cocrystals—A Review †

Buddhadev, Sheetal; Garala, Kevin (Proceedings Journals (MDPI), 2020-11)

The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with ...
Design and Development of Microemulsion Based Transdermal Gel of Lercanidipine Hydrochloride by Assimilation of Rotatable Central Composite Design and Principal Component Analysis

Dhingani, Anjali; Patel, Jaydeep; Garala, Kevin; Dharamsi, Abhay (Pharmaceutical Nanotechnology, Bentham Science Publishers, 2013)

The objective of the present research was to design and develop microemulsion (ME) based transdermal systems of poorly water soluble drug, Lercanidipine hydrochloride (LDPH) by assimilation of central composite design and ...
Quality by Design Approach for Development of W/O Type Microemulsion Based Transdermal Systems for Atenolol

Dhingani, Anjali; Patel, Jaydeep; Garala, Kevin; Raval, Mihir; Dharamsi, Abhay (Journal of Dispersion Science and Technology, 2013-07)

The objective of the present investigation was to develop microemulsion (ME) based transdermal systems of highly water soluble drug, Atenolol by quality by design technique. Atenolol loaded W/O MEs were optimized using ...
Quality by design approach for oral bioavailability enhancement of Irbesartan by self-nanoemulsifying tablets

Patel, Jaydeep; Dhingani, Anjali; Garala, Kerala; Raval, Mihir; Sheth, Navin (Informa healthcare, 2016)

The present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the investigation, IRB-loaded self-nanoemulsifying ...
Design and development of solid nanoparticulate dosage forms of telmisartan for bioavailability enhancement by integration of experimental design and principal component analysis

Patel, Jaydeep; Dhingani, Anjali; Garala, Kevin; Raval, Mihir; Sheth, Navin (Powder Technology, Elsevier, 2014-03)

Aim of the present investigation was to develop nanoparticulate solid oral dosage forms of a poorly water soluble antihypertensive agent, telmisartan (TLM) by converting the optimized batch of drug loaded nanosuspensions into ...
Formulation and evaluation of periodontal in situ gel

Garala, Kevin; Joshi, Parth; Shah, Malay; Ramkishan, A; Patel, Jaydeep (International Journal of Pharmaceutical Investigation, 2013-01)

Temperature‑sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochloride was formulated by cold method using different polymers. Preliminary study was carried out to optimize different types and concentration ...
Influence of Crosslinking Agent on the Release of Drug from the Matrix Transdermal Patches of HPMC/Eudragit RL 100 Polymer Blends

Garala, Kevin; Shah, Pratik (Journal of Macromolecular Science, Part A, 2010-01)

The present work was designed to develop suitable transdermal matrix patches using the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit RL100 (ERL) with triethyl citrate as a plasticizer in group A ...
Enhanced encapsulation of metoprolol tartrate with carbon nanotubes as adsorbent

Garala, Kevin; Patel, Jaydeep; Patel, Anjali; Dharamsi, Abhay (Applied Nanoscience (Springer), 2011-09)

A highly water-soluble antihypertensive drug, metoprolol tartrate (MT), was selected as a model drug for preparation of multi-walled carbon nanotubes (MWCNTs)- impregnated ethyl cellulose (EC) microspheres. The present ...
Quality by design (QbD) approach for developing agglomerates containing racecadotril and loperamide hydrochloride by crystallo-co-agglomeration

Garala, Kevin; Patel, Jaydeep; Dhingani, Anjali; Dharamsi, Abhay (Powder Technology, Elsevier, 2013)

This research presents the use of experimental design, optimization and multivariate techniques to investigate the root-cause of agglomerates containing two drugs [i.e. racecadotril (RCD) and loperamide hydrochloride (LPM)]. ...
Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: An integrated approach of principal component analysis and Box–Behnken experimental design

Garala, Kevin; Patel, Jaydeep; Dhingani, Anjali; Dharamsi, Abhay (International Journal of Pharmaceutics (Elsevier), 2013-04)

Poor mechanical properties of crystalline drug particles require wet granulation technique for tablet production which is uneconomical, laborious, and tedious. The present investigation was aimed to improve flow and ...
Design and Release Kinetic Studies of Nimesulide Bioadhesive Topical Gel

Joshi, Bansari; Dalal, Grishma; Bavlia, Jalpa; Biswajit, Basu; Garala, Kevin; Vadalia, K. (Inventi Journals, 2016-08)

The objective of the present investigation was to develop topical gel of nimesulide using model polymers such as hydroxypropyl methylcellulose K100M (HPMC K100M) and carbopol 940 at different concentrations individually ...
In-Vitro Anti-inflammatory Activity of Traditionally reported Poly Herbal Combination

Manvar, Mital (Asian Journal of Pharmacy and Technology, 2023-03)

Inflammatory diseases are still one of the most important heath-problems in the world. Most of anti inflammatory drugs such as non–steroidal anti-inflammatory drugs (NSAIDS) have number of adverse effects hence there are ...
Antibacterial Activity of Leaves and Flowers of Ipomoea aquatica Forsk. (Convolvulacea)

Manvar, Mital (Asian Journal of Pharmaceutical Research (AJPRes.), 2018-06)

Man has been using herbs and plants products for combating diseases since times immemorial. Up till now, however, all antimicrobial substances from higher plants have been found either to be toxic to animals or not ...
Exploration of possible mechanisms for anti-inflammatory activity of Ipomoea aquatica Forsk. (Convolvulaceae)

Manvar, Mital; Desai, T. (International Journal of Phytopharmacy (Scholar Science Journals), 2015-10)

Currently used steroidal and non steroidal anti-inflammatory drugs have severe side effects. These side effects are very difficult to manage than the disease itself. Hence, there is to search new safe resources to cure ...
In-vitro Anti-inflammatory and Anti-Arthritic Activities of Fruits of Vernonia anthelmintica Willd. (Asteraceae)

Manvar, Mital; Desai, T. (Asian Pharma Press, 2014)

Hydroalcoholic extract of fruits of Vernonia anthelmintica Willd. (Family: Asteraceae) (HAEVA) was assessed for its anti-inflammatory activity and anti-arthritic activity by in vitro methods. In vitro anti-inflammatory ...

Now showing items 81-100 of 111

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