Design, Synthesis and Evaluation of Antimicrobial Activities of Some Novel 2-Mercapto-1,3,4-Oxadiazo-2-Yl Derivatives Clubbed With 1hbenzimidazole.

Abstract

A series of N-(substitutedphenyl)-2-(1-((5-mercapto-1,3,4-oxadiazol-2-yl)methyl)-1H-benzo[d] imidazol-2-ylthio)acetamide5 (A-H),2-(1H-benzo[d]imidazol-2-ylthio)-N-(4-(5-(substituted benzyl or pyridinylmethylthio)-1,3,4-oxadiazole-2-yl)phenyl)acetamide5(J-M)&2-(1H-benzo[d]imidazol-2-ylthio)-N-(4-(5-(2-(arylamino)-2-oxo-ethylthio)-1,3,4-oxadiazol-2-yl)phenyl)phenyl) acetamide5 (N-S) were prepared by the reaction of carbon disulphide with corresponding acid hydrazides 4 (A-H).On the other compounds 5(J-M) &5 (N-S)were prepared by the reaction of various benzyl halides or pyridinyl methyl halide and various chloroacetylated amines with 2-(1H-benzo[d]imidazol-2-ylthio)-N-(4-(5-mercapto-1,3,4-oxadiazo-2-yl)phenyl)acetamide 5I. All the synthesized compounds were characterized by IR, 1H NMR, and mass spectral technique and evaluated for their antimicrobial activity.