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Design, Synthesis and Evaluation of Antimicrobial Activities of Some Chalcone & Schiff base Derivatives Clubbed with 1H-Benzimidazole

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dc.contributor.author Gadhiya, Bipin.
dc.contributor.author Rajput, Mahesh.
dc.contributor.author Bapodra, Atul H.
dc.contributor.author Ladva, Kartik.
dc.date.accessioned 2021-08-17T11:02:55Z
dc.date.available 2021-08-17T11:02:55Z
dc.date.issued 2016-02-01
dc.identifier.citation Gadhiya, B. D., Rajput, M. R., Bapodra, A. H., & Ladva, K. D. (2016). Design, Synthesis and Evaluation of Antimicrobial Activities of Some Chalcone & Schiff base Derivatives Clubbed with 1H-Benzimidazole.Der Pharma Chemica, 8(16), 40-47. en_US
dc.identifier.issn 0975-413X
dc.identifier.uri https://www.derpharmachemica.com/archive/dpc-volume-8-issue-16-year-2016.html
dc.identifier.uri http://10.9.150.37:8080/dspace//handle/atmiyauni/682
dc.description.abstract A series of 2-(1H-benzo[d]imidazol-2-ylthio)-3-(substitutedphenyl)-1-(substitutedphenyl) prop-2-en-1-one 3 (A-L) derivatives have been synthesized via Claisen-schmidt reaction of different aromatic aldehydes with 2- benzimidazolyl thioacetophenone 2(A-D) derivatives and these 2-mercaptobenzimidazolyl acetophenone derivatives which in turn synthesized by condensation of various acetophenones with 2-mercaptobenzimidazole 1A & 6-methoxy-2-mercaptobenzimidazole 1B. On the other hand desired Schiff base derivatives N-(3-chlorophenyl)-2-(1-(2-hydrazinyl-2-oxoethyl)-1H-benzo[d]imidazol-2-ylthio)acetamide 7(A-H) have been prepared in three successive steps which comprised of synthesis of ethyl 2-(2-(2-(3-chloro phenyl amino)-2-oxoethylthio)-1H-enzo[d]imidazol- 1-yl) acetate 5 its corresponding hydrazide N-(3-chloro phenyl)-2-(1-(2-hydrazinyl-2-oxoethyl)-1Hbenzo[d]imidazol-2-ylthio) acetamide 6 and finally Schiff base derivatives via acid catalyzed condensation reactionof various aldehydes with this hydrazide. All the synthesized compounds were characterized by IR, 1H NMR and mass spectral techniques and evaluated for their antimicrobial activity. en_US
dc.language.iso en_US en_US
dc.publisher Der Pharma Chemica en_US
dc.subject Chalcones, Schiff base, Benzimidazole, Antimicrobial activities en_US
dc.title Design, Synthesis and Evaluation of Antimicrobial Activities of Some Chalcone & Schiff base Derivatives Clubbed with 1H-Benzimidazole en_US
dc.type Article en_US


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