Abstract:
Substituted chalcones 2a-m have been synthesized by the treatment of 2-chloro-6-methyl-3-quinolincarboxaldehyde1 with different aromatic ketones.
Subsequent reaction with phenyl hydrazine in ethanol furnished desired pyrazolines 3a-m. The compounds [2a-m, 3a-m] have been characterised by means of elemental analyses and spectral data. The products were evaluated for their in vitro growth
inhibiting activity against several microbes. Some of the compounds showed significant biological activity.
