Abstract:
Cyanopyridine derivatives shows good biological and therapeutic
activities, With a view of getting to synthesized 2-Amino-6-aryl-4-
{[(3′-difluoromethoxy)-5′-(3′′-methyl)-4′′-(2′′′,2′′′,2′′′-trifluoroethoxy)
pyridin-2′′-yl]methoxyphenyl}-nicotinonitriles (3a-3k) by the
condensation of (E)-3-{[(3′-difluoromethoxy)-5′-(3″-methyl)-4″-
(2‴,2‴,2‴-trifluoroethoxy) pyridine-2-yl] methoxy phenyl}-1-aryl-prop-
2-ene-1-ones with malononitrile in presence of ammonium acetate. All
Synthesized compounds characterized by TLC, IR, 1HNMR, Mass
spectra and Physical constants. All the synthesized compounds
screened for their antimicrobial activity against Gram +ve bacteria
(B.mega, B.Subtillis) Gram -ve bacteria (E.coli, P.fluorescens) and fungi (A.awamori).
