Abstract:
Acetyl pyrazoline derivatives procuring shows better therapeutic activity looking at their versatile therapeutic importance and with an aim to getting to synthesize some new pyrazolines. The synthesis of 1-{3-[4’-(diabenzo[b, f][1,4]thiazepin-11”-l)amino]phenyl}-5-aryl-1-H-pyrazol-1-yl-ethanone have been synthesis by the cyclo condensation of
chalcones(5a-5j)with hydrazine hydrate and glacial acetic acid. The constitution of the products has been characterized by elemental analyses IR, 1H NMR and Mass spectral study. The products were screened for their antimicrobial activity against Gram +ve bacteria Gram negative bacteria and fungi at 50 μg concentration by cup-plate method.
